ArticleHead & neck2022
Association of low skeletal muscle mass and systemic inflammation with surgical complications and survival after microvascular flap reconstruction in patients with head and neck cancer.
Article in Head & neck, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Association between malnutrition and prognosis in colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Sarcopenia predicts postoperative complications in head and neck cancer: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Pooled it
- Low Skeletal Muscle Mass as a Key Predictor of Postoperative Diet Outcomes in Circumferential Hypopharyngeal Cancer Reconstruction.Laryngoscope investigative otolaryngology · 2026Article
- CT-Defined Low Skeletal Muscle Mass Predicts Early Swallowing and Quality-of-Life Recovery After Head-and-Neck Oncologic Reconstruction.Diagnostics (Basel, Switzerland) · 2026Article
- Impact of C3 Vertebra-Based Sarcopenia and Clinical Factors on Postoperative Complications in Oral Cancer Patients.Cancers · 2026Article
- Artificial Intelligence Approaches to Predict Postoperative Length of Hospital Stay in Head and Neck Cancer Patients: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Validation of the Controlling Nutritional Status (CONUT) Score and the Systemic Immune-Inflammation Index (SII) for Predicting Leakage and Surgical Complications After Head and Neck Free Flap Reconstruction: A Pilot Study.Medicina (Kaunas, Lithuania) · 2025Article
- Perioperative Nutritional and Metabolic Factors Affecting Surgical Outcomes in Head and Neck Cancer Free Flap Reconstruction: A Comprehensive Review.Journal of clinical medicine · 2025Review
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- Early Postoperative Increase in Transforming Growth Factor Beta-1 Predicts Microvascular Flap Loss in Reconstructive Surgery: A Prospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Observational
- Low Skeletal Muscle Mass: A Strong Predictive Factor for Surgical Complications After Free Forearm Flap Reconstruction in Oral Cancer Patients.Head & neck · 2025Article
- Novel Challenges and Opportunities for Anesthesia and Perioperative Care in Microvascular Flap Surgery: A Narrative Review.Clinics and practice · 2024Review
- Von Willebrand Factor Antigen, Biomarkers of Inflammation, and Microvascular Flap Thrombosis in Reconstructive Surgery.Journal of clinical medicine · 2024Article
- Muscle mass as a modifier of stress response in acute ischemic stroke patients.Scientific reports · 2024Article
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Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkeletal muscle mass (SMM) and chronic inflammation are associated with postoperative complications and survival.
methodsPatients with head and neck cancer (HNC) undergoing microvascular free flap reconstruction were included. SMM and neutrophil-to-lymphocyte ratio (NLR) were measured and their association with treatment outcomes analyzed.
resultsFive hundred and fifty-four patients were included. Predictors for complications were elevated NLR in all flaps (OR 1.5), low SMM in radial forearm flap (OR 2.0), and elevated NLR combined with low SMM in fibula flap surgery (OR 4.3). Patients with solely elevated NLR were at risk for flap-related complications (OR 3.0), severe complications (OR 2.2), and when combined with low SMM for increased length of hospital stays (LOS) (+3.9 days). In early-stage HNC, low SMM (HR 2.3), and combined elevated NLR with low SMM (HR 2.6) were prognostics for decreased overall survival.
conclusionsSMM and NLR are predictive for poor outcomes in patients with HNC undergoing microvascular reconstruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.