Evidence map›Paper›PMID 35652248›Full record

ArticleMedical physics2022

Application of a novel diamond detector for commissioning of FLASH radiotherapy electron beams.

Gianluca Verona Rinati, Giuseppe Felici, Federica Galante, Alessia Gasparini, Rafael Kranzer, Giulia Mariani, Matteo Pacitti, Giuseppe Prestopino, Andreas Schüller, Verdi Vanreusel and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Gianluca Verona RinatiDepartment of Industrial Engineering, University of Rome Tor Vergata, Rome, Italy.
Giuseppe FeliciSIT S.p.A., Latina, Italy.
Federica GalanteSIT S.p.A., Latina, Italy.
Alessia GaspariniIridium Kankernetwerk, Antwerp, Belgium.
Rafael KranzerPTW-Freiburg, Freiburg im Breisgau, Germany.
Giulia MarianiSIT S.p.A., Latina, Italy.
Matteo PacittiSIT S.p.A., Latina, Italy.
Giuseppe PrestopinoDepartment of Industrial Engineering, University of Rome Tor Vergata, Rome, Italy.
Andreas SchüllerPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany.
Verdi VanreuselIridium Kankernetwerk, Antwerp, Belgium.
Dirk VerellenIridium Kankernetwerk, Antwerp, Belgium.
Claudio VeronaDepartment of Industrial Engineering, University of Rome Tor Vergata, Rome, Italy.
Marco MarinelliDepartment of Industrial Engineering, University of Rome Tor Vergata, Rome, Italy.
Rina Services (Italy) · ITUniversity of Rome Tor Vergata · ITUniversity of Antwerp · BEPhysikalisch-Technische Bundesanstalt · DEUniversity of Freiburg · DE

Funding

European Metrology Programme for Innovation and Research
6 · The paper itself

Abstract

purposeA diamond detector prototype was recently proposed by Marinelli et al. (Medical Physics 2022, https://doi.org/10.1002/mp.15473) for applications in ultrahigh-dose-per-pulse (UH-DPP) and ultrahigh-dose-rate (UH-DR) beams, as used in FLASH radiotherapy (FLASH-RT). In the present study, such so-called flashDiamond (fD) was investigated from the dosimetric point of view, under pulsed electron beam irradiation. It was then used for the commissioning of an ElectronFlash linac (SIT S.p.A., Italy) both in conventional and UH-DPP modalities.

methodsDetector calibration was performed in reference conditions, under

resultsThe fD calibration coefficient resulted to be independent from the investigated beam qualities. The detector response was found to be linear in the whole investigated DPP range. A very good agreement was observed among PDDs, beam profiles, and OFs measured by the fD prototype and reference detectors, both in conventional and UH-DPP irradiation modalities.

conclusionsThe fD detector prototype was validated from the dosimetric point of view against several commercial dosimeters in conventional beams. It was proved to be suitable in UH-DPP and UH-DR conditions, for which no other commercial real-time active detector is available to date. It was shown to be a very useful tool to perform fast and reproducible beam characterizations in standard clinical motorized water phantom setups. All of the previously mentioned demonstrate the suitability of the proposed detector for the commissioning of UH-DR linac beams for preclinical FLASH-RT applications.

Indexed as

DiamondElectronsParticle AcceleratorsRadiometryWaterDiamondWaterdiamond detectordosimetryFLASH radiotherapy

Identifiers

PMID35652248
PMCPMC9543846
OpenAlexW4281965185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.