Evidence map›Paper›PMID 35652166›Full record

ArticleAdvanced biology2022

Multiomic Analyses of Nascent Preterm Infant Microbiomes Differentiation Suggest Opportunities for Targeted Intervention.

Stephanie B Orchanian, Julia M Gauglitz, Stephen Wandro, Kelly C Weldon, Megan Doty, Kristina Stillwell, Shalisa Hansen, Lingjing Jiang, Fernando Vargas, Kyung E Rhee and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. A Scoping Review of the Oral Microbiome in Preterm Infants.American journal of perinatology · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Stephanie B OrchanianCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-2491-1074
Julia M GauglitzCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0003-3146-2489
Stephen WandroCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-5514-0244
Kelly C WeldonCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0003-1064-8153
Megan DotyDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0003-2136-3719
Kristina StillwellDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0003-2785-8245
Shalisa HansenCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.
Lingjing JiangDivision of Biostatistics, University of California San Diego, La Jolla, CA, 92093, USA.
Fernando VargasSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-5847-2439
Kyung E RheeCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.
Julie C LumengDepartment of Pediatrics, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-7898-8210
Pieter C DorresteinCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-3003-1030
Rob KnightCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-0975-9019
Jae H KimDepartment of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-6321-2594
Se Jin SongCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0003-0750-5709
Austin D SwaffordCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-5655-8300
University of California San Diego · USUniversity of Michigan · US

Funding

The Development of Eating Behavior in Infancy: Associations with Behavior, Diet, and Growth to Age 6 yearsR01HD084163 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C · 2015 to 2024
$6.3M
NICHD NIH HHS R01 HD084163
6 · The paper itself

Abstract

The first week after birth is a critical time for the establishment of microbial communities for infants. Preterm infants face unique environmental impacts on their newly acquired microbiomes, including increased incidence of cesarean section delivery and exposure to antibiotics as well as delayed enteral feeding and reduced human interaction during their intensive care unit stay. Using contextualized paired metabolomics and 16S sequencing data, the development of the gut, skin, and oral microbiomes of infants is profiled daily for the first week after birth, and it is found that the skin microbiome appears robust to early life perturbation, while direct exposure of infants to antibiotics, rather than presumed maternal transmission, delays microbiome development and prevents the early differentiation based on body site regardless of delivery mode. Metabolomic analyses identify the development of all gut metabolomes of preterm infants toward full-term infant profiles, but a significant increase of primary bile acid metabolism only in the non-antibiotic treated vaginally birthed late preterm infants. This study provides a framework for future multi-omic, multibody site analyses on these high-risk preterm infant populations and suggests opportunities for monitoring and intervention, with infant antibiotic exposure as the primary driver of delays in microbiome development.

Indexed as

Gastrointestinal MicrobiomeInfant, Newborn, DiseasesMicrobiotaCesarean SectionFemaleHumansInfantInfant, NewbornInfant, PrematureMetabolomePregnancyantibioticsdelivery modeearly neonatal developmentmicrobiomepreterm infant

Identifiers

PMID35652166
PMCPMC10321678
OpenAlexW4281867931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.