Evidence map›Paper›PMID 35652132›Full record

ArticleJournal of veterinary pharmacology and therapeutics2022

Pharmacokinetics of grapiprant and effects on TNF-alpha concentrations following oral administration to horses.

Silke L Hoffmann, Kelsey Seminoff, Daniel S McKemie, Philip H Kass, Heather K Knych

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary pharmacology and therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Single-Dose Pharmacokinetics of Grapiprant in Rhesus Macaques (Macaca mulatta).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Silke L HoffmannK.L Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, California, USA.
Kelsey SeminoffK.L Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, California, USA.
Daniel S McKemieK.L Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, California, USA.
Philip H KassDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA.
Heather K KnychK.L Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, California, USA.ORCID https://orcid.org/0000-0002-8676-4970
University of California, Davis · US

Funding

Students Training in Advanced Research (STAR) ProgramT35OD010956 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DANIKA L BANNASCH · 2012 to 2026
$1.6M
NIH HHS T35 OD010956
6 · The paper itself

Abstract

Grapiprant is a prostaglandin E

Indexed as

HorsesSulfonylurea CompoundsTumor Necrosis Factor-alphaAdministration, OralAnimalsArea Under CurveBenzenesulfonamidesHalf-LifeImidazolesProstaglandins EPyridinesBenzenesulfonamidesgrapiprantImidazolesProstaglandins EPyridinesSulfonylurea CompoundsTumor Necrosis Factor-alphagrapipranthorseNSAIDpharmacokineticsTNF alpha

Identifiers

PMID35652132
PMCPMC10919302
OpenAlexW4281664949

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.