Evidence map›Paper›PMID 35652116›Full record

ArticleRadiology. Artificial intelligence2022

Artificial Intelligence with Statistical Confidence Scores for Detection of Acute or Subacute Hemorrhage on Noncontrast CT Head Scans.

Eli Gibson, Bogdan Georgescu, Pascal Ceccaldi, Pierre-Hugo Trigan, Youngjin Yoo, Jyotipriya Das, Thomas J Re, Vishwanath Rs, Abishek Balachandran, Eva Eibenberger and 9 more

Open access · greenAbstract read
In one paragraph

Article in Radiology. Artificial intelligence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 3 countries.

Eli GibsonDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0001-9207-7280
Bogdan GeorgescuDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0001-5388-5699
Pascal CeccaldiDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0001-9536-5990
Pierre-Hugo TriganDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0003-1139-2022
Youngjin YooDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0002-0001-0503
Jyotipriya DasDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).
Thomas J ReDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).
Vishwanath RsDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0002-9494-471X
Abishek BalachandranDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0002-3726-7839
Eva EibenbergerDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0003-3560-830X
Andrei ChekkouryDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0003-3651-6298
Barbara BrehmDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).
Uttam K BodanapallyDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0003-0455-816X
Savvas NicolaouDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0002-4203-6605
Pina C SanelliDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0002-9633-3699
Thomas J SchroeppelDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0001-9164-5004
Thomas FlohrDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).
Dorin ComaniciuDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0002-5238-8647
Yvonne W LuiDepartment of Digital Technology and Innovation, Siemens Healthineers, 755 College Rd E, Princeton, NJ 08540 (E.G., B.G., P.C., P.H.T., Y.Y., J.D., T.J.R., D.C.); Department of Digital Technology and Innovation, Siemens Healthineers, Bangalore, India (V.R.S., A.B.); Department of Computed Tomography, Siemens Healthineers, Forchheim, Germany (E.E., A.C., B.B., T.F.); Department of Radiology, University of Maryland Medical Center, Baltimore, Md (U.K.B.); Department of Radiology, Vancouver General Hospital, Vancouver, Canada (S.N.); Department of Radiology, Northwell Health, New York, NY (P.C.S.); Department of Surgery, UCHealth Memorial Hospital, Colorado Springs, Colo (T.J.S.); and Department of Radiology, NYU Langone Health, New York University School of Medicine, New York, NY (Y.W.L.).ORCID https://orcid.org/0000-0002-9984-9164
University of Maryland, Baltimore · US

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dmitry S Novikov · 2014 to 2026
$19.3M
NIBIB NIH HHS P41 EB017183
6 · The paper itself

Abstract

Purpose: To present a method that automatically detects, subtypes, and locates acute or subacute intracranial hemorrhage (ICH) on noncontrast CT (NCCT) head scans; generates detection confidence scores to identify high-confidence data subsets with higher accuracy; and improves radiology worklist prioritization. Such scores may enable clinicians to better use artificial intelligence (AI) tools. Materials and Methods: This retrospective study included 46 057 studies from seven "internal" centers for development (training, architecture selection, hyperparameter tuning, and operating-point calibration; Results: The areas under the receiver operating characteristic curve for ICH were 0.97 (0.97, 0.98) and 0.95 (0.94, 0.95) on internal and external center data, respectively. On 80% of the data stratified by calibrated classifier and Dempster-Shafer scores, the system improved the Youden indexes, increasing them from 0.84 to 0.93 (calibrated classifier) and from 0.84 to 0.92 (Dempster-Shafer) for internal centers and increasing them from 0.78 to 0.88 (calibrated classifier) and from 0.78 to 0.89 (Dempster-Shafer) for external centers ( Conclusion: AI that provided statistical confidence measures for ICH detection on NCCT scans reliably detected and subtyped hemorrhages, identified high-confidence predictions, and improved worklist prioritization in simulation.

Indexed as

Convolutional Neural Network (CNN)CTHead/NeckHemorrhage

Identifiers

PMID35652116
PMCPMC9152881
OpenAlexW4224289711

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.