Evidence map›Paper›PMID 35652004›Full record

ArticleFrontiers in human neuroscience2022

Influence of Previous General Anesthesia on Cognitive Impairment: An Observational Study Among 151 Patients.

Federico Linassi, Alessandro De Laurenzis, Eleonora Maran, Alessandra Gadaldi, Leonardo Spano', Gino Gerosa, Demetrio Pittarello, Paolo Zanatta, Michele Carron

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Federico LinassiDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Alessandro De LaurenzisDepartment of Medicine, Anaesthesiology and Intensive Care, University of Padova, Padova, Italy.
Eleonora MaranDepartment of Medicine, Anaesthesiology and Intensive Care, University of Padova, Padova, Italy.
Alessandra GadaldiDepartment of Medicine, Anaesthesiology and Intensive Care, University of Padova, Padova, Italy.
Leonardo Spano'Department of Medicine, Anaesthesiology and Intensive Care, University of Padova, Padova, Italy.
Gino GerosaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Demetrio PittarelloDepartment of Medicine, Anaesthesiology and Intensive Care, University of Padova, Padova, Italy.
Paolo ZanattaDepartment of Anesthesia and Intensive Care, Integrated University Hospital of Verona, Verona, Italy.
Michele CarronDepartment of Medicine, Anaesthesiology and Intensive Care, University of Padova, Padova, Italy.
University of Padua · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Preoperative neurocognitive disorder (preO-NCD) is a common condition affecting 14-51. 7% of the elderly population. General anesthesia has already been associated with the one-year post-operative neurocognitive disorder (PostO-NCD), specifically, a deficit in executive function, measured by the Trail Making Test B (TMT-B), but its long-term effects on cognitive function have not been investigated. We aimed to detect preO-NCD prevalence in patients scheduled for cardiac surgery and further investigate the possible role of previous general anesthesia (pGA) in general preoperative cognitive status [measured Methods: In this observational, prospective study, 151 adult patients scheduled for elective cardiac surgery underwent MoCA and TMT-B. Data on age, education, pGA, comorbidities, and laboratory results were collected. Results: We discovered a general cognitive function impairment of 79.5% and an executive function impairment of 22%. Aging is associated with an increased likelihood (OR 2.99, Conclusion: We found a high prevalence of preO-NCD in patients scheduled for cardiac surgery. General cognitive function impairment is highly associated with advancing age (not pGA). However, older patients with at least one pGA appeared to be at an increased risk of preO-NCD, especially executive function impairment, suggesting that TMT-B should be associated with MoCA in the preoperative cognitive evaluation in this population.

Indexed as

agecardiac surgerycomorbiditiesgeneral anesthesiapre-operative neurocognitive disorder

Identifiers

PMID35652004
PMCPMC9148968
OpenAlexW4280540546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.