ReviewFrontiers in cardiovascular medicine2022
Carotid Plaque Composition and the Importance of Non-Invasive in Imaging Stroke Prevention.
Review in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Duplex ultrasound for surveillance of lower limb revascularisation.The Cochrane database of systematic reviews · 2023Pooled it
- Plaque-Level Machine Learning Prediction of Intraplaque Hemorrhage in Carotid Arteries Using Computed Tomography Angiography.Clinical neuroradiology · 2026Article
- Proteomics reveals spatial and molecular heterogeneities in advanced atherosclerotic carotid artery plaques.Nature cardiovascular research · 2026Article
- Assessment of carotid atherosclerotic plaque vulnerability with multi-radiotracer PET/CT: a scoping review.European radiology · 2026Review
- Investigating the association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and the risk of carotid artery plaque in patients with first-ever ischemic stroke based on different glucose metabolic conditions.Frontiers in endocrinology · 2026Article
- Systematic Review of the Discrepancies Between Guideline Recommendations on Carotid Revascularization in Patients with Symptomatic Carotid Artery Disease.Stroke (Hoboken, N.J.) · 2025Article
- Carotid plaque characteristics by computed Tomography: A diagnostic accuracy systematic review.International journal of cardiology. Heart & vasculature · 2025Review
- Elucidating the Relationship between Neutrophil-Lymphocyte Ratio and Plaque Composition in Patients with Drug-Eluting Stent Restenosis by Virtual Histology-Intravascular Ultrasound.Journal of cardiovascular development and disease · 2024Article
- Associations between carotid plaque shape, biomechanical parameters, and ischemic stroke in mild carotid stenosis with a single plaque.Ultrasonography (Seoul, Korea) · 2024Article
- Findings of Angiography and Carotid Vessel Wall Imaging Associated with Post-Procedural Clinical Events after Carotid Artery Stenting.Neurointervention · 2024Article
- Accuracy of duplex ultrasonography versus angiotomography for the diagnosis of extracranial internal carotid stenosis.Revista do Colegio Brasileiro de Cirurgioes · 2024Article
- The prevalence of extracranial carotid atherosclerosis detected via ultrasound imaging: A single-centre study in Jeddah, Saudi Arabia.Saudi medical journal · 2024Article
- Article
- Contrast-Enhanced Ultrasound Feasibility in Assessing Carotid Plaque Vulnerability-Narrative Review.Journal of clinical medicine · 2023Review
- Novel Imaging-Based Biomarkers for Identifying Carotid Plaque Vulnerability.Biomolecules · 2023Review
- MR Imaging of Carotid Artery Atherosclerosis: Updated Evidence on High-Risk Plaque Features and Emerging Trends.AJNR. American journal of neuroradiology · 2023Review
- Calcification circumference, area, and location are associated with carotid stent expansion rate: high-resolution magnetic resonance vessel wall imaging study.Quantitative imaging in medicine and surgery · 2023Article
- Carotid massive intraplaque hemorrhage, lipid-rich necrotic core, and heavy circumferential calcification were associated with new ipsilateral ischemic cerebral lesions after carotid artery stenting: high-resolution magnetic resonance vessel wall imaging study.Cardiovascular diagnosis and therapy · 2023Article
- microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician's Perspective.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Luminal stenosis has been the standard feature for the current management strategies in patients with atherosclerotic carotid disease. Histological and imaging studies show considerable differences between plaques with identical degrees of stenosis. They indicate that specific plaque characteristics like Intraplaque hemorrhage, Lipid Rich Necrotic Core, Plaque Inflammation, Thickness and Ulceration are responsible for the increased risk of ischemic events. Intraplaque hemorrhage is defined by the accumulation of blood components within the plaque, Lipid Rich Necrotic Core is composed of macrophages loaded with lipid, Plaque Inflammation is defined as the process of atherosclerosis itself and Plaque thickness and Ulceration are defined as morphological features. Advances in imaging methods like Magnetic Resonance Imaging, Ultrasound, Computed Tomography and Positron Emission Tomography have enabled a more detailed characterization of the plaque, and its vulnerability is linked to these characteristics, changing the management of these patients based only on the degree of plaque stenosis. Studies like Rotterdam, ARIC, PARISK, CAPIAS and BIOVASC were essential to evaluate and prove the relevance of these characteristics with cerebrovascular symptoms. A better approach for the prevention of stroke is needed. This review summarizes the more frequent carotid plaque features and the available validation from recent studies with the latest evidence.
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