Evidence map›Paper›PMID 35651726›Full record

ArticleOxidative medicine and cellular longevity2022

Markers of Inflammation, Oxidative Stress, and Fibrosis in Patients with Atrial Fibrillation.

Priit Pauklin, Mihkel Zilmer, Jaan Eha, Kaspar Tootsi, Mart Kals, Priit Kampus

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Trajectory of Cardiogenic Dementia: A New Perspective.Journal of cellular and molecular medicine · 2025
    Review
  8. Article
  9. Evaluation of Galectin-3 in Dogs with Atrial Fibrillation.Animals : an open access journal from MDPI · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. The role of galectin-3 in atrial fibrillation.Journal of molecular medicine (Berlin, Germany) · 2023
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Priit PauklinDepartment of Cardiology, Institute of Clinical Medicine, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia.ORCID https://orcid.org/0000-0003-3259-9962
Mihkel ZilmerDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, Centre of Excellence for Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, Tartu 50411, Estonia.ORCID https://orcid.org/0000-0002-1337-594X
Jaan EhaDepartment of Cardiology, Institute of Clinical Medicine, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia.ORCID https://orcid.org/0000-0001-5049-4852
Kaspar TootsiDepartment of Traumatology and Orthopedics, Institute of Clinical Medicine, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia.ORCID https://orcid.org/0000-0003-2151-9031
Mart KalsEstonian Genome Center, Institute of Genomics, University of Tartu, 23b Riia Street, Tartu 51010, Estonia.ORCID https://orcid.org/0000-0003-2090-8780
Priit KampusDepartment of Cardiology, Institute of Clinical Medicine, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia.ORCID https://orcid.org/0000-0003-1320-6967
Tartu University Hospital · EEUniversity of Tartu · EENorth Estonia Medical Centre · EEUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice. The pathogenesis of AF is linked to inflammatory reaction and oxidative stress, which leads to fibrosis of the atria and progression of the disease. The purpose of this study was to define the role of several biomarkers of inflammation, fibrosis, and oxidative stress (OxS). We included 75 patients with paroxysmal/persistent AF, who were admitted for electrical cardioversion or pulmonary vein isolation (PVI). High-sensitivity C-reactive protein (hsCRP), galectin-3 (Gal-3), myeloperoxidase (MPO), oxidized low-density lipoprotein (oxLDL), and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured before the procedures. We compared the results with those of 75 healthy age-, sex-, and blood pressure-matched individuals. The patients were followed up for 1 year after the intervention to establish the recurrence of AF and its association with the measured markers. Patients with AF had higher MPO (52.6 vs. 36.2 ng/ml,

Indexed as

Atrial FibrillationBiomarkersC-Reactive ProteinFibrosisHumansInflammationOxidative StressBiomarkersC-Reactive Protein

Identifiers

PMID35651726
PMCPMC9150993
OpenAlexW4281395964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.