Evidence map›Paper›PMID 35651361›Full record

ArticleERJ open research2022

Acoustic surveillance of cough for detecting respiratory disease using artificial intelligence.

Juan C Gabaldón-Figueira, Eric Keen, Gerard Giménez, Virginia Orrillo, Isabel Blavia, Dominique Hélène Doré, Nuria Armendáriz, Juliane Chaccour, Alejandro Fernandez-Montero, Javier Bartolomé and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07212439 (Continuous Cough Monitoring for Early Detection of COPD Exacerbations Using Hyfe), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07212439 recruitingnot on this mapstarted 2025, after this paper: background citation

Continuous Cough Monitoring for Early Detection of COPD Exacerbations Using Hyfe

Typeobservational_patient_registrySponsorClinica Universidad de Navarra, Universidad de NavarraRan2025 to 2026Enrolled50ConditionsChronic Obstructive Pulmonary Disease (COPD)
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Cough biomarkers for diagnosis and monitoring of respiratory disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Article
  12. Article
  13. Measuring cough: what really matters?Journal of thoracic disease · 2023
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Juan C Gabaldón-FigueiraDept of Microbiology and Infectious Diseases, Clinica Universidad de Navarra, Pamplona, Spain.ORCID https://orcid.org/0000-0002-2525-0263
Eric KeenResearch and Development Dept, Hyfe Inc, Wilmington, DE, USA.
Gerard GiménezResearch and Development Dept, Hyfe Inc, Wilmington, DE, USA.
Virginia OrrilloSchool of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Isabel BlaviaSchool of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Dominique Hélène DoréImmunopathology Axis, Research Center of the University of Montreal Hospital Center, Montréal, QC, Canada.
Nuria ArmendárizPrimary Healthcare, Navarra Health Service-Osasunbidea, Zizur Mayor, Spain.
Juliane ChaccourDept of Microbiology and Infectious Diseases, Clinica Universidad de Navarra, Pamplona, Spain.ORCID https://orcid.org/0000-0001-9812-050X
Alejandro Fernandez-MonteroDept of Occupational Medicine - COVID-19 Area, Clinica Universidad de Navarra, Pamplona, Spain.
Javier BartoloméPrimary Healthcare, Navarra Health Service-Osasunbidea, Zizur Mayor, Spain.
Nita UmashankarFowler College of Business, San Diego State University, San Diego, CA, USA.
Peter SmallResearch and Development Dept, Hyfe Inc, Wilmington, DE, USA.
Simon Grandjean LapierreImmunopathology Axis, Research Center of the University of Montreal Hospital Center, Montréal, QC, Canada.ORCID https://orcid.org/0000-0003-3646-1573
Carlos ChaccourDept of Microbiology and Infectious Diseases, Clinica Universidad de Navarra, Pamplona, Spain.ORCID https://orcid.org/0000-0001-9812-050X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research question: Can smartphones be used to detect individual and population-level changes in cough frequency that correlate with the incidence of coronavirus disease 2019 (COVID-19) and other respiratory infections? Methods: This was a prospective cohort study carried out in Pamplona (Spain) between 2020 and 2021 using artificial intelligence cough detection software. Changes in cough frequency around the time of medical consultation were evaluated using a randomisation routine; significance was tested by comparing the distribution of cough frequencies to that obtained from a model of no difference. The correlation between changes of cough frequency and COVID-19 incidence was studied using an autoregressive moving average analysis, and its strength determined by calculating its autocorrelation function (ACF). Predictors for the regular use of the system were studied using a linear regression. Overall user experience was evaluated using a satisfaction questionnaire and through focused group discussions. Results: We followed-up 616 participants and collected >62 000 coughs. Coughs per hour surged around the time cohort subjects sought medical care (difference +0.77 coughs·h Interpretation: Artificial intelligence systems can detect changes in cough frequency that temporarily correlate with the onset of clinical disease at the individual level. A clearer correlation with population-level COVID-19 incidence, or other respiratory conditions, could be achieved with better penetration and compliance with cough monitoring.

Identifiers

PMID35651361
PMCPMC9149391

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.