ArticleACS macro letters2018
Optical Tweezers Microrheology: From the Basics to Advanced Techniques and Applications.
Article in ACS macro letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 110 citations in OpenAlex.
- Real-Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Active and probe-free intracellular rheology via phase-sensitive thermoviscous flows.PNAS nexus · 2026Article
- Macrophages Mediate Mesoscale Brain Mechanical Homeostasis.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Attonewton Force Resolution Measurements with Silicon Nanospheres at the Thermal Noise Limit in Ambient-Temperature Liquids.Nano letters · 2025Article
- Microrheology: From Video Microscopy to Optical Tweezers.Micromachines · 2025Review
- Kinesin-Driven De-Mixing of Cytoskeleton Composites Drives Emergent Mechanical Properties.Macromolecular rapid communications · 2025Article
- FAIR data for optical tweezers experiments.Biophysical journal · 2025Review
- The mechanobiology of biomolecular condensates.Biophysics reviews · 2025Review
- Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology.Nature nanotechnology · 2025Article
- Ligand presentation controls collective MSC response to matrix stress relaxation in hybrid PEG-HA hydrogels.Bioactive materials · 2025Article
- Viscoelasticity of ECM and cells-origin, measurement and correlation.Mechanobiology in medicine · 2024Review
- Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites.Soft matter · 2024Article
- Article
- Mathematical Models for Ultrasound Elastography: Recent Advances to Improve Accuracy and Clinical Utility.Bioengineering (Basel, Switzerland) · 2024Review
- Sequence-specific interactions determine viscoelasticity and aging dynamics of protein condensates.Nature physics · 2024Article
- Viscoelasticity in 3D Cell Culture and Regenerative Medicine: Measurement Techniques and Biological Relevance.ACS materials Au · 2024Review
- Optical tweezers microrheology maps micro-mechanics of complex systems.Trends in biochemical sciences · 2024Article
- 3D-printed ultra-small Brownian viscometers.Scientific reports · 2024Article
- Multiscale elasticity mapping of biological samples in 3D at optical resolution.Acta biomaterialia · 2024Article
- Molecular Rotors: Fluorescent Sensors for Microviscosity and Conformation of Biomolecules.Angewandte Chemie (International ed. in English) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Over the past few decades, microrheology has emerged as a widely used technique to measure the mechanical properties of soft viscoelastic materials. Optical tweezers offer a powerful platform for performing microrheology measurements and can measure rheological properties at the level of single molecules out to near macroscopic scales. Unlike passive microrheology methods, which use diffusing microspheres to extract rheological properties, optical tweezers can probe the nonlinear viscoelastic response, and measure the space- and time-dependent rheological properties of heterogeneous, nonequilibrium materials. In this Viewpoint, I describe the basic principles underlying optical tweezers microrheology, the instrumentation and material requirements, and key applications to widely studied soft biological materials. I also describe several sophisticated approaches that include coupling optical tweezers to fluorescence microscopy and microfluidics. The described techniques can robustly characterize noncontinuum mechanics, nonlinear mechanical responses, strain-field heterogeneities, stress propagation, force relaxation dynamics, and time-dependent mechanics of active materials.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.