Evidence map›Paper›PMID 35650665›Full record

ReviewAnnual review of microbiology2022

Genomic Approaches to Antifungal Drug Target Identification and Validation.

Nicole Robbins, Leah E Cowen

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Primed for Discovery.Biochemistry · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; email: leah.cowen@utoronto.ca.
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; email: leah.cowen@utoronto.ca.
University of Toronto · CA

Funding

Systematic Analysis of Morphogenesis, Commensalism, and Virulence in a Leading Human Fungal PathogenR01AI127375 · NIAID · UNIVERSITY OF TORONTO · PI LEAH Elizabeth Cowen · 2017 to 2026
$5.3M
Targeting Hsp90 in cryptococcal fungal pathogenesisR01AI120958 · NIAID · UNIVERSITY OF TORONTO · PI BROWN, LAUREN ELAINE, COWEN, LEAH ELIZABETH · 2016 to 2019
$3.2M
Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesisR01AI162789 · NIAID · UNIVERSITY OF TORONTO · PI LEAH Elizabeth Cowen, Timothy M Willson · 2022 to 2026
$3.1M
NIAID NIH HHS R01 AI120958NIAID NIH HHS R01 AI127375NIAID NIH HHS R01 AI162789
6 · The paper itself

Abstract

The last several decades have witnessed a surge in drug-resistant fungal infections that pose a serious threat to human health. While there is a limited arsenal of drugs that can be used to treat systemic infections, scientific advances have provided renewed optimism for the discovery of novel antifungals. The development of chemical-genomic assays using

Indexed as

Antifungal AgentsCryptococcus neoformansCandida albicansGenomicsHumansSaccharomyces cerevisiaeAntifungal AgentsantifungalCandidachemical genomicsCryptococcusfungal pathogensSaccharomyces cerevisiae

Identifiers

PMID35650665
PMCPMC10727914
OpenAlexW4281747822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.