ArticleBMC endocrine disorders2022
Comparison of the prognostic value of AJCC cancer staging system 7th and 8th editions for differentiated thyroid cancer.
Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 5 citations in OpenAlex.
- Epidemiology, risk factor and prognostic factor of young differentiated thyroid carcinoma with distant metastasis: a retrospective cohort study.American journal of cancer research · 2026Article
- Article
- Optimal cut-off age for AJCC staging system in Middle Eastern differentiated thyroid cancer.Frontiers in endocrinology · 2025Article
- A novel proportional index to differentiate between demographically and clinically matched cases with papillary thyroid carcinoma or non-cancerous nodule: PLR-to-PDW ratio.American journal of translational research · 2023Article
- Preoperative prognostic risk stratification model for papillary thyroid carcinoma based on clinical and ultrasound characteristics.Frontiers in endocrinology · 2022Article
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8 authors at 2 institutions in 1 country.
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Abstract
backgroundIn the last American Joint Committee on Cancer/Tumor, Node, Metastasis (AJCC/TNM) 8th edition (TNM8), several changes were introduced to this risk stratification system to improve the prognosis of differentiated thyroid cancer (DTC).
aimTo validate the impact of TNM8 vs. TNM 7th edition (TNM7) in DTC in terms of predictive value in two hospitals from Buenos Aires, Argentina.
methodsRetrospective study of DTC patients from two institutions. Reclassification from TNM7 to TNM8, disease-specific survival (DSS), and final clinical outcomes at the end of follow-up (recurrent/persistent structural disease) (median 5 years) were analyzed. The proportion of variation explained (PVE) was used to compare the predictive capability of DSS of both classification systems.
resultsReclassification of 245 patients, aged (mean ± SD) 55 ± 15.36 years, 91% women, to TNM8 from TNM7 showed: 82% vs 57% stage I (SI), 10% vs 8.5% SII, 5% vs 22% SIII, 3% vs 12% SIV (p < 0.01). Forty percent of the population was downstaged with TNM8. Ten-year DSS rates for SI, SII, SIII and SIV in TNM7 were 100, 100, 100 and 74%, respectively and in TNM8: 97.6, 100, 100 and 37.5%, respectively. Out of 4 disease-specific deaths in SIV TNM7, one was subclassified to SI TNM8, corresponding to a 53-year-old patient with structural persistence. PVE for TNM8 (29%) was more than twice that of TNM7 (13%).
conclusionIn this Argentinian DTC patients sample, it was confirmed that the new TNM8 classification is more accurate in predicting survival attributable to cancer than its previous version.
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