ArticleBMC medicine2022
Adiposity and grip strength: a Mendelian randomisation study in UK Biobank.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Predictive Value of Musculoskeletal Fitness for Cardiovascular Risk Factors in Adolescents with Congenital Heart Disease: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Handgrip Strength and Trajectories of Preclinical Obesity Progression: A Multistate Model Analysis Using the UK Biobank.The Journal of clinical endocrinology and metabolism · 2026Article
- Grip strength: are some adiposity phenotypes more detrimental than others? A Mendelian randomization study.Obesity (Silver Spring, Md.) · 2025Observational
- Healthy lifestyle, daytime sleepiness, and gut microbiome composition are determinants of functional strength in humans: a cross-sectional study.Scientific reports · 2025Article
- Unpicking Causal Relationships Between Grip Strength and Cardiorespiratory Fitness: A Bidirectional Mendelian Randomization Study.Scandinavian journal of medicine & science in sports · 2024Article
- The Causal Effect of Adult Height on Late-Life Handgrip Strength: The Singapore Chinese Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Muscle Mass and Muscle Strength in Non-Dialysis-Dependent Chronic Kidney Disease Patients.Journal of clinical medicine · 2024Article
- Association between sarcopenic obesity and knee osteoarthritis: A narrative review.Osteoarthritis and cartilage open · 2024Article
- Predictors of Hand Grip Strength in Adults Without Sarcopenia: Data From the NHANES, 2013-2014.Current developments in nutrition · 2024Article
- Longitudinal association of grip strength with cardiovascular and all-cause mortality in older urban Lithuanian population.BMC public health · 2024Article
- Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Handgrip Strength and Clinical Evolution of People Living with HIV: A Mini Narrative Review.Current HIV research · 2024Review
- Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study.Scientific reports · 2023Article
- Article
- Linear and Nonlinear Associations Between Vitamin D and Grip Strength: A Mendelian Randomization Study in UK Biobank.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Article
- Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMuscle weakness, which increases in prevalence with age, is a major public health concern. Grip strength is commonly used to identify weakness and an improved understanding of its determinants is required. We aimed to investigate if total and central adiposity are causally associated with grip strength.
methodsUp to 470,786 UK Biobank participants, aged 38-73 years, with baseline data on four adiposity indicators (body mass index (BMI), body fat percentage (BF%), waist circumference (WC) and waist-hip-ratio (WHR)) and maximum grip strength were included. We examined sex-specific associations between each adiposity indicator and grip strength. We explored whether associations varied by age, by examining age-stratified associations (< 50 years, 50-59 years, 60-64 years,65 years +). Using Mendelian randomisation (MR), we estimated the strength of the adiposity-grip strength associations using genetic instruments for each adiposity trait as our exposure.
resultsIn males, observed and MR associations were generally consistent: higher BMI and WC were associated with stronger grip; higher BF% and WHR were associated with weaker grip: 1-SD higher BMI was associated with 0.49 kg (95% CI: 0.45 kg, 0.53 kg) stronger grip; 1-SD higher WHR was associated with 0.45 kg (95% CI:0.41 kg, 0.48 kg) weaker grip (covariate adjusted observational analyses). Associations of BMI and WC with grip strength were weaker at older ages: in males aged < 50 years and 65 years + , 1-SD higher BMI was associated with 0.93 kg (95% CI: 0.84 kg, 1.01 kg) and 0.13 kg (95% CI: 0.05 kg, 0.21 kg) stronger grip, respectively. In females, higher BF% was associated with weaker grip and higher WC was associated with stronger grip; other associations were inconsistent.
conclusionsUsing different methods to triangulate evidence, our findings suggest causal links between adiposity and grip strength. Specifically, higher BF% (in both sexes) and WHR (males only) were associated with weaker grip strength.
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