Evidence map›Paper›PMID 35650456›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

The effect of aerobic exercise on tumour blood delivery: a systematic review and meta-analysis.

Catherine Seet-Lee, Jasmine Yee, Heidi Morahan, Lois S Ross, Kate M Edwards

2 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07554677 narecruitingnot on this mapstarted 2026, after this paper: background citation

Feasibility of a Co-designed PRe-radiotherapy Exercise Programme for People With Stage I-III Non-small Cell Lung cAnCEr: A Single-centre, Single Arm Pilot Study

TypeinterventionalSponsorQueen's University, BelfastRan2026 to 2026Enrolled30ConditionsLung CancerArmsExercise, radiotherapy
NCT07785882 nanot yet recruitingnot on this mapstarted 2027, after this paper: background citation

Sarcoma and Intra-infusion Exercise for Better Outcomes: The SEB-trial

TypeinterventionalSponsorKira BloomquistRan2027 to 2028Enrolled16ConditionsSarcomaArmsExercise
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Catherine Seet-LeeFaculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.ORCID https://orcid.org/0000-0002-8744-3343
Jasmine YeeFaculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.ORCID https://orcid.org/0000-0001-9058-8212
Heidi MorahanFaculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.ORCID https://orcid.org/0000-0003-2469-1566
Lois S RossFaculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.
Kate M EdwardsFaculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia. kate.edwards@sydney.edu.au.ORCID http://orcid.org/0000-0003-3429-5989
The University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTumour blood vessels are structurally and functionally abnormal, resulting in areas of hypoxia and heterogeneous blood supply. Aerobic exercise may modulate tumour blood flow and normalise the tumour microenvironment to improve chemotherapy delivery. This systematic review and meta-analysis aimed to evaluate the effect of the aerobic exercise mode on tumour hypoxia, vascularisation and blood flow.

methodsFour online databases were searched. Preclinical and clinical randomised controlled trials examining the effects of aerobic exercise training on hypoxia, vascularisation or blood flow in solid tumours were included. The risk of bias was assessed and a meta-analysis performed.

resultsSeventeen preclinical studies and one clinical study met criteria. Eleven studies assessed hypoxia, 15 studies assessed vascularisation and seven evaluated blood flow. There was large variability in measurement methods, tumour types and exercise program designs. The overall risk of bias was unclear in clinical and preclinical studies, owing to poor reporting. There was no significant effect of aerobic exercise on hypoxia (SMD = -0.17; 95% CI = -0.62, 0.28; I

conclusionThere is heterogeneity in methodology, resulting in evidence that is inconsistent and inconclusive for the effects of aerobic exercise on hypoxia, vascularisation and blood flow. Most evidence of aerobic exercise effects on tumour blood flow is in animal models, with very limited evidence in humans.

Indexed as

ExerciseNeoplasmsExercise TherapyHumansHypoxiaTumor MicroenvironmentBlood flowExerciseHypoxiaTumourVascularisation

Identifiers

PMID35650456
PMCPMC9633495
OpenAlexW4281743134

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.