ArticleNature2022
Clonal dynamics of haematopoiesis across the human lifespan.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 332 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
332citing papers in PubMed, 1 pooled it
67.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
332 citing papers in PubMed, 1 synthesis or guideline pooled it, 458 citations in OpenAlex.
- Effects of donor-engrafted clonal hematopoiesis in allogeneic and autologous stem cell transplantation: a systematic review and meta-analysis.Bone marrow transplantation · 2024Pooled it
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- Systemic delivery of phagocytosis-shielded retroviral vectors enables in vivo HSC gene therapy for sickle cell disease.Cell stem cell · 2026Article
- Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis.Nature immunology · 2026Article
- A guide to understanding tumour evolution through the lens of population genetics.Nature reviews. Cancer · 2026Review
- Genetic mechanisms of mitotic error in 840,853 blood genomes.medRxiv : the preprint server for health sciences · 2026Article
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- Tet2 deficiency drives age-related heterogeneous progression of myeloid neoplasms through epigenetic-immune microenvironment imbalance.Journal of translational medicine · 2026Article
- The Evolution of Polyclonal Competition in Aging Hematopoiesis.Cancer discovery · 2026Article
- Lifelong phylogenetic reconstruction of immune-mediated clonal trajectories in paroxysmal nocturnal hemoglobinuria.Leukemia · 2026Article
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- Bone as a Biomarker of Ageing and Senescence: Connecting Musculoskeletal Health to Longevity via Diet, Nutrition and Exercise.Biology · 2026Review
- Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle.Science (New York, N.Y.) · 2026Article
- Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026Review
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- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- Understanding the somatic evolution of metabolic traits.Nature metabolism · 2026Article
- Article
- Article
272 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
29 authors at 5 institutions in 2 countries.
Emily MitchellWellcome Sanger Institute, Hinxton, UK.
Michael Spencer Chapman *Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-5320-8193
Nicholas Williams *Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-3989-9167
Kevin J Dawson *Wellcome Sanger Institute, Hinxton, UK.
Nicole MendeWellcome-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-5078-2333
Emily F CalderbankWellcome-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-9559-6593
Hyunchul JungWellcome Sanger Institute, Hinxton, UK.
Thomas MitchellWellcome Sanger Institute, Hinxton, UK.
Tim H H CoorensWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-5826-3554
David H SpencerDepartment of Medicine, McDonnell Genome Institute, Washington University, St Louis, MO, USA.
Heather MachadoWellcome Sanger Institute, Hinxton, UK.
Henry Lee-SixWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-4831-8088
Megan DaviesCambridge Molecular Diagnostics, Milton Road, Cambridge, UK.
Daniel HaylerWellcome-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.
Margarete A FabreWellcome Sanger Institute, Hinxton, UK.
Krishnaa MahbubaniDepartment of Surgery, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1327-2334
Federico AbascalWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-6201-1587
Alex CaganWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-7857-4771
George S VassiliouWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-4337-8022
Joanna BaxterDepartment of Haematology, University of Cambridge, Cambridge, UK.
Inigo MartincorenaWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-1122-4416
Michael R StrattonWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-6035-153X
David G KentYork Biomedical Research Institute, Department of Biology, University of York, York, UK.ORCID http://orcid.org/0000-0001-7871-8811
Krishna ChatterjeeWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-2654-8854
Kourosh Saeb ParsyDepartment of Surgery, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0633-3696
Anthony R GreenWellcome-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK.
Jyoti NangaliaWellcome Sanger Institute, Hinxton, UK. jn5@sanger.ac.uk.ORCID http://orcid.org/0000-0001-7122-4608
Elisa LaurentiWellcome-MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, UK. el422@cam.ac.uk.ORCID http://orcid.org/0000-0002-9917-9092
Peter J CampbellWellcome Sanger Institute, Hinxton, UK. pc8@sanger.ac.uk.ORCID http://orcid.org/0000-0002-3921-0510
Wellcome Sanger Institute · GBWellcome/MRC Cambridge Stem Cell Institute · GBUniversity of Cambridge · GBJames S. McDonnell Foundation · USUniversity of York · GB
Funding
Cancer Research UK 21777Cancer Research UK 23917Cancer Research UK 27176European Research Council ERC-2016-STG-715371Medical Research Council MC_PC_17230Wellcome Trust 210755/Z/18/ZWellcome Trust WT088340MA
Abstract
Age-related change in human haematopoiesis causes reduced regenerative capacity
Indexed as
AgingClonal HematopoiesisClone CellsLongevityAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHematologic NeoplasmsHematopoietic Stem CellsHumansInfantInfant, Newborn
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.