Evidence map›Paper›PMID 35650332›Full record

ArticleDrug delivery and translational research2022

Enhancing the function of PLGA-collagen scaffold by incorporating TGF-β1-loaded PLGA-PEG-PLGA nanoparticles for cartilage tissue engineering using human dental pulp stem cells.

Parisa Ghandforoushan, Jalal Hanaee, Zahra Aghazadeh, Mohammad Samiei, Amir Mohammad Navali, Ali Khatibi, Soodabeh Davaran

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In one paragraph

Article in Drug delivery and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  4. Recent Developments in Nanoparticle-Hydrogel Hybrid Materials for Controlled Release.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Parisa GhandforoushanStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID 0000-0001-5036-1195
Jalal HanaeeDepartment of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Zahra AghazadehStem Cell Research Center, Oral Medicine Department, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad SamieiDepartment of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Amir Mohammad NavaliDepartment of Orthopedy, Tabriz University of Medical Sciences, Tabriz, Iran.
Ali KhatibiDepartment of Biotechnology, Alzahra University, Tehran, Iran.
Soodabeh DavaranStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. davaran@tbzmed.ac.ir.ORCID 0000-0002-7072-2362
Tabriz University of Medical Sciences · IRAlzahra University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since cartilage has a limited capacity for self-regeneration, treating cartilage degenerative disorders is a long-standing difficulty in orthopedic medicine. Researchers have scrutinized cartilage tissue regeneration to handle the deficiency of cartilage restoration capacity. This investigation proposed to compose an innovative nanocomposite biomaterial that enhances growth factor delivery to the injured cartilage site. Here, we describe the design and development of the biocompatible poly(lactide-co-glycolide) acid-collagen/poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-collagen/PLGA-PEG-PLGA) nanocomposite hydrogel containing transforming growth factor-β1 (TGF-β1). PLGA-PEG-PLGA nanoparticles were employed as a delivery system embedding TGF-β1 as an articular cartilage repair therapeutic agent. This study evaluates various physicochemical aspects of fabricated scaffolds by

Indexed as

NanoparticlesTissue EngineeringBiocompatible MaterialsCartilageCell DifferentiationCollagenDental PulpHumansLactic AcidNanogelsPolyestersPolyethylene GlycolsPolyglactin 910Polyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerSpectroscopy, Fourier Transform InfraredBiocompatible MaterialsCollagenLactic AcidNanogelsPolyesterspolyethylene glycol-poly(lactide-co-glycolide)Polyethylene GlycolsPolyglactin 910Polyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerTransforming Growth Factor beta1BiocompatibilityCartilage regenerationCollagenNanocomposite hydrogelScaffoldTissue engineering

Identifiers

PMID35650332
OpenAlexW4281861332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.