ArticleNature communications2022
Cloning of the broadly effective wheat leaf rust resistance gene Lr42 transferred from Aegilops tauschii.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Advances in gene cloning and functional genomics approaches for wheat (Triticum aestivum L.) improvement.The plant genome · 2026Review
- Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Dissecting adult plant resistance to stripe and leaf rust in advanced Indian wheat breeding lines through a genome-wide association study.BMC plant biology · 2026Article
- The effect of nine-year nitrogen addition on foliar fungal diseases of plant groups in an alpine meadow.Frontiers in plant science · 2026Article
- Genome-wide association study of seedling leaf rust resistance in European winter wheat cultivars.Journal of applied genetics · 2025Article
- Hunting for the genetic loci underlying root lodging resistance by BSR-seq and QTL mapping in maize.BMC plant biology · 2025Article
- Genome-assisted identification of wheat leaf rust resistance gene Lr.ace-4A/Lr30.Nature communications · 2025Article
- Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.Nature plants · 2025Article
- An atypical NLR pair TdCNL1/TdCNL5 from wild emmer confers powdery mildew resistance in wheat.Nature genetics · 2025Article
- Development and validation of a new co-dominant DNA marker for selecting the null allele of polyphenol oxidase geneBreeding science · 2025Article
- Genetic dissection of leaf rust resistance in a diversity panel of tetraploid wheat (Triticum turgidum).BMC plant biology · 2025Article
- Fine mapping of the unique Ur-11 gene conferring broad resistance to the rust pathogen of common bean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Identification of leaf rust resistance loci in hard winter wheat using genome-wide association mapping.The plant genome · 2025Article
- AcRLK2P-1, an LRR receptor protein kinase gene from Agropyron cristatum, confers leaf rust resistance in wheat.Plant communications · 2024Article
- Puccinia triticina avirulence protein AvrLr21 directly interacts with wheat resistance protein Lr21 to activate wheat immune response.Communications biology · 2024Article
- Wheat improvement through advances in single nucleotide polymorphism (SNP) detection and genotyping with a special emphasis on rust resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Metabolome and Mycobiome ofPlants (Basel, Switzerland) · 2024Article
- Fine-mapping of LrN3B on wheat chromosome arm 3BS, one of the two complementary genes for adult-plant leaf rust resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Development and identification of a novel wheat-Thinopyrum ponticum disomic substitution line DS5Ag(5D) with new genes conferring resistance to powdery mildew and leaf rust.BMC plant biology · 2024Article
- Genome-wide atlas of rust resistance loci in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
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23 authors.
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Abstract
The wheat wild relative Aegilops tauschii was previously used to transfer the Lr42 leaf rust resistance gene into bread wheat. Lr42 confers resistance at both seedling and adult stages, and it is broadly effective against all leaf rust races tested to date. Lr42 has been used extensively in the CIMMYT international wheat breeding program with resulting cultivars deployed in several countries. Here, using a bulked segregant RNA-Seq (BSR-Seq) mapping strategy, we identify three candidate genes for Lr42. Overexpression of a nucleotide-binding site leucine-rich repeat (NLR) gene AET1Gv20040300 induces strong resistance to leaf rust in wheat and a mutation of the gene disrupted the resistance. The Lr42 resistance allele is rare in Ae. tauschii and likely arose from ectopic recombination. Cloning of Lr42 provides diagnostic markers and over 1000 CIMMYT wheat lines carrying Lr42 have been developed documenting its widespread use and impact in crop improvement.
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