ArticleLight, science & applications2022
Transport of intensity diffraction tomography with non-interferometric synthetic aperture for three-dimensional label-free microscopy.
Article in Light, science & applications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 155 citations in OpenAlex.
- Article
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- Inverse scattering in biological samples via beam propagation.Science advances · 2026Article
- ARF-like GTPase 8B orchestrates lipophagy and exocytosis to drive single-stranded RNA virus replication.Journal of translational medicine · 2026Article
- Inverse-scattering of absorptive samples via beam propagation.bioRxiv : the preprint server for biology · 2026Article
- Analytic Fourier ptychotomography for aberration-free and high-resolution volumetric refractive index imaging.Nature communications · 2025Article
- Advanced automated classification and segmentation of leukemic cells using simulated optical scanning holography and active contour methods.Journal of biomedical optics · 2025Article
- Multi-modal transport of intensity diffraction tomography microscopy with an electrically tunable lens [Invited].Biomedical optics express · 2025Article
- Gelatin-Based Soft-Tissue Sarcoma Organoids Recapitulate Patient Tumor Characteristics.Biomaterials research · 2025Article
- Quantitative phase imaging endoscopy with a metalens.Light, science & applications · 2024Article
- Transport-of-intensity phase imaging using commercially available confocal microscope.Journal of biomedical optics · 2024Article
- Ultrabroadband Optical Diffraction Tomography.ACS photonics · 2024Article
- Lens-free on-chip 3D microscopy based on wavelength-scanning Fourier ptychographic diffraction tomography.Light, science & applications · 2024Article
- TowardsFundamental research · 2024Review
- Quantitative phase imaging based on holography: trends and new perspectives.Light, science & applications · 2024Review
- Perspective on quantitative phase imaging to improve precision cancer medicine.Journal of biomedical optics · 2024Article
- Alternating projection combined with fast gradient projection (FGP-AP) method for intensity-only measurement optical diffraction tomography in LED array microscopy.Biomedical optics express · 2024Article
- Recent Advances and Current Trends in Transmission Tomographic Diffraction Microscopy.Sensors (Basel, Switzerland) · 2024Review
- Innovative stain-free technique for high-resolution imaging of virus particles via standard transmission electron microscopy.Heliyon · 2024Article
- High spatiotemporal-resolution mapping for a seasonal erosion flooding inundation using time-series Landsat and MODIS images.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We present a new label-free three-dimensional (3D) microscopy technique, termed transport of intensity diffraction tomography with non-interferometric synthetic aperture (TIDT-NSA). Without resorting to interferometric detection, TIDT-NSA retrieves the 3D refractive index (RI) distribution of biological specimens from 3D intensity-only measurements at various illumination angles, allowing incoherent-diffraction-limited quantitative 3D phase-contrast imaging. The unique combination of z-scanning the sample with illumination angle diversity in TIDT-NSA provides strong defocus phase contrast and better optical sectioning capabilities suitable for high-resolution tomography of thick biological samples. Based on an off-the-shelf bright-field microscope with a programmable light-emitting-diode (LED) illumination source, TIDT-NSA achieves an imaging resolution of 206 nm laterally and 520 nm axially with a high-NA oil immersion objective. We validate the 3D RI tomographic imaging performance on various unlabeled fixed and live samples, including human breast cancer cell lines MCF-7, human hepatocyte carcinoma cell lines HepG2, mouse macrophage cell lines RAW 264.7, Caenorhabditis elegans (C. elegans), and live Henrietta Lacks (HeLa) cells. These results establish TIDT-NSA as a new non-interferometric approach to optical diffraction tomography and 3D label-free microscopy, permitting quantitative characterization of cell morphology and time-dependent subcellular changes for widespread biological and medical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.