Evidence map›Paper›PMID 35650126›Full record

ArticleInternal medicine (Tokyo, Japan)2022

Somatostatin Receptor-negative and Fluorodeoxyglucose-positron Emission Tomography-positive Lung Neuroendocrine Tumor G1 Exhibiting Cyclic Cushing's Syndrome.

Chiaki Nomura, Yujiro Nakano, Takeo Tanaka, Kosuke Robert Shima, Mitsuhiro Kometani, Takehiro Kanamori, Hiroko Ikeda, Yumie Takeshita, Takashi Yoneda, Toshinari Takamura

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chiaki NomuraDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Japan.
Yujiro NakanoDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Japan.
Takeo TanakaDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Japan.
Kosuke Robert ShimaDepartment of Diabetes, Endocrinology and Metabolism, Koseiren Takaoka Hospital, Japan.
Mitsuhiro KometaniDepartment of Health Promotion and Medicine of the Future, Kanazawa University Graduate School of Medical Sciences, Japan.
Takehiro KanamoriDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Japan.
Hiroko IkedaDepartment of Diagnostic Pathology, Kanazawa University Hospital, Japan.
Yumie TakeshitaDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Japan.
Takashi YonedaDepartment of Health Promotion and Medicine of the Future, Kanazawa University Graduate School of Medical Sciences, Japan.
Toshinari TakamuraDepartment of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Japan.
Kanazawa University · JPKanazawa University Hospital · JPKouseiren Takaoka Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Localization of ectopic cyclic Cushing's syndrome, which causes life-threatening complications, is challenging. A 70-year-old woman showed cyclic hypokalemia and hyperglycemia and was diagnosed with cyclic ectopic Cushing's syndrome. Although somatostatin-receptor scintigraphy failed to localize the responsible tumor, fluorodeoxyglucose-positron emission tomography (FDG-PET) showed the uptake of tracer in a lung tumor. Lobectomy resulted in remission. The resected adrenocorticotropic hormone (ACTH)-producing neuroendocrine tumor had Ki-67<2% and negative staining for somatostatin receptors. This is the first case assessed both radiological findings and pathological findings in cyclic ectopic Cushing's syndrome. Subsequent FDG-PET is recommended if somatostatin-receptor scintigraphy is negative.

Indexed as

ACTH Syndrome, EctopicCarcinoid TumorCarcinoma, NeuroendocrineCushing SyndromeLung NeoplasmsNeuroendocrine TumorsAgedFemaleFluorodeoxyglucose F18HumansLungPositron-Emission TomographyReceptors, SomatostatinSomatostatinFluorodeoxyglucose F18Receptors, SomatostatinSomatostatinACTH-producing tumorcyclicFDG-PETsomatostatin-receptor

Identifiers

PMID35650126
PMCPMC9841091
OpenAlexW4282934312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.