Evidence map›Paper›PMID 35650123›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Endothelial Damage-dominant Nephritis Related to IgA Vasculitis after 11 Years' Use of Infliximab for Rheumatoid Arthritis.

Makoto Fukuda, Naoki Sawa, Daisuke Ikuma, Yuki Oba, Hiroki Mizuno, Masayuki Yamanouchi, Akinari Sekine, Eiko Hasegawa, Tatsuya Suwabe, Junichi Hoshino and 6 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Makoto FukudaDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Naoki SawaDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Daisuke IkumaDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Yuki ObaDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Hiroki MizunoDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Masayuki YamanouchiDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Akinari SekineDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Eiko HasegawaDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Tatsuya SuwabeDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Junichi HoshinoDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Kei KonoDepartment of Pathology, Toranomon Hospital, Japan.
Keiichi KinowakiDepartment of Pathology, Toranomon Hospital, Japan.
Kenichi OhashiDepartment of Pathology, Toranomon Hospital, Japan.
Hiromichi TamakiImmuno-Rheumatology Center, St. Luke's International Hospital, Japan.
Motoaki MiyazonoDepartment of Nephrology, Saga University Internal Medicine, Japan.
Yoshifumi UbaraDepartment of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, Japan.
Toranomon Hospital · JPSaga University · JPSt. Luke's International Hospital · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 43-year-old Japanese woman with rheumatoid arthritis treated by infliximab and methotrexate for 11 years was admitted for proteinuria and purpura. A kidney biopsy revealed endothelial damage-dominant nephritis with IgA deposition. Infliximab and methotrexate were discontinued, and tocilizumab was started; however, proteinuria persisted. Therefore, tocilizumab was discontinued, and oral prednisolone and methylprednisolone pulse therapy were administered. After 6 months, urinary protein was less than 0.1 g/day, and purpura subsided. To our knowledge, this is the first case of endothelial damage-dominant nephritis related to IgA vasculitis involving the skin and kidney after long-term use of infliximab and methotrexate.

Indexed as

Arthritis, RheumatoidIgA VasculitisNephritisPurpuraAdultFemaleHumansInfliximabMethotrexateProteinuriaInfliximabMethotrexateendocapillary glomerulonephritisIgA vasculitisrheumatoid arthritistocilizumab

Identifiers

PMID35650123
PMCPMC9876708
OpenAlexW4282928056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.