Observational studyJournal of pain and symptom management2022
Quality of Life in Adolescents and Young Adults: The Role of Symptom Burden.
Observational study in Journal of pain and symptom management, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A Dutch paediatric palliative care guideline: a systematic review and evidence-based recommendations for symptom treatment.BMC palliative care · 2024Guideline
- Effect of Acupuncture and Massage on Pain in Adolescent and Young Adult Patients with Advanced Cancer: Subgroup Analysis of a Randomized Clinical Trial.Journal of adolescent and young adult oncology · 2026Trial
- Integrating Electronic Patient-Reported Outcomes and Palliative Care in Pediatric Advanced Cancer: The PediQUEST Response Multisite Randomized Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026Trial
- Sleep quality and disturbances in adolescents and young adults with cancer compared to a healthy comparison group: results of the AYA-LE study.Journal of cancer research and clinical oncology · 2026Observational
- Family Environment Factors Associated with Symptom Distress Among Korean Adolescents and Young Adults with Cancer: A Cross-Sectional Study.Current oncology (Toronto, Ont.) · 2026Article
- Home-based symptom management for patients with malignant lymphoma undergoing intermittent chemotherapy: A prospective observational study using network analysis.Asia-Pacific journal of oncology nursing · 2025Article
- Health-Related Quality of Life in Adolescents and Young Adults With an Uncertain or Poor Cancer Prognosis: Quantitative Baseline Results of the CORD-AYA Study.Psycho-oncology · 2025Article
- Symptom Burden in Adolescents and Young Adults With Cancer.JAMA network open · 2025Article
- Diet in adolescent and young adult patients with cancer and cancer survivors: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Navigating an uncertain future: a qualitative study exploring thoughts about fertility and oncofertility counseling among young men with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Identifying Weekly Trajectories of Pain Severity Using Daily Data From an mHealth Study: Cluster Analysis.JMIR mHealth and uHealth · 2024Article
- Development of Quality of Life in Adolescents and Young Adults With Cancer Using a Patient Support Smartphone App: Prepost Interventional Study.JMIR cancer · 2023Article
- Symptom severity and trajectories among adolescent and young adult patients with cancer.JNCI cancer spectrum · 2023Article
- "I won't get to live my life the way I planned it": A qualitative analysis of the experiences of adolescents and young adults with advanced cancer.Pediatric blood & cancer · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
contextAdolescents and young adults (AYAs) with cancer report worse health-related quality of life (HRQOL) than other age groups. Symptom burden is a modifiable predictor of HRQOL.
objectivesThe objective of this study was to identify which symptoms are most burdensome to AYAs with advanced cancer.
methodsIn this observational study, English-speaking individuals aged 12-25 years undergoing treatment for advanced cancer completed assessments of symptom burden (Memorial Symptom Assessment Scale) and HRQOL (Pediatric Quality of Life Inventory Generic Form and Cancer Module; minimal clinically important difference 4.4). We dichotomized participants as having low (<7) or high (≥7) symptom prevalence. Mixed regression models estimated HRQOL differences between groups. For individual symptoms, unadjusted mixed models estimated HRQOL reductions.
resultsN = 58 AYAs completed baseline surveys. The median age was 17 years (IQR 15-19), 58% were male, 59% identified as white, and 44% were diagnosed with leukemia/lymphoma. High symptom prevalence was associated with a mean generic HRQOL 7 points lower (95% CI: -11, -3; P < 0.01) and cancer-specific HRQOL score 12 points lower (95% CI: -17, -7; P < 0.01) than low symptom prevalence. The most prevalent symptoms were fatigue (71%), pain (58%), and difficulty sleeping (58%). Fatigue (-8), difficulty concentrating (-7), and mouth sores (-6) were associated with the greatest generic HRQOL score reductions. Dysphagia (-12), difficulty concentrating (-12), and sadness (-11) were associated with the greatest cancer-specific HRQOL score reductions.
conclusionThe symptom experience among AYAs with advanced cancer is unique. Separate evaluation of AYA's symptoms may optimize management and improve HRQOL.
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