ArticleCell reports2022
Intestinal inflammation alters the antigen-specific immune response to a skin commensal.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- The Gut-Skin Axis in Atopic Dermatitis and Inflammatory Bowel Disease: Mechanisms, Microbiota, and Therapeutic Implications.Journal of personalized medicine · 2026Review
- Intestinal Barrier Loss Enables Microbiota-Mediated Purinergic Suppression During Malaria.bioRxiv : the preprint server for biology · 2026Article
- Engineering Multi-Scale Transdermal Delivery Systems for Atopic Dermatitis: Emerging Insights from the Gut-Skin Axis.International journal of nanomedicine · 2026Review
- From intestinal immune niches to systemic inflammation: programming cellular plasticity and immune redistribution across organs.Frontiers in immunology · 2026Review
- The human skin microbiome in health.Journal of the American Academy of Dermatology · 2025Review
- Article
- Advances in Microbiome-Based Therapeutics for Dermatological Disorders: Current Insights and Future Directions.Experimental dermatology · 2024Review
- Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients.Scientific reports · 2024Article
- Immune cell trafficking: a novel perspective on the gut-skin axis.Inflammation and regeneration · 2024Review
- A dynamic atlas of immunocyte migration from the gut.Science immunology · 2024Article
- Biofilm-derived oxylipin 10-HOME-mediated immune response in women with breast implants.The Journal of clinical investigation · 2023Article
- Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.Immunity · 2023Article
- Potential Association ofMicroorganisms · 2023Review
- Unraveling the gut-skin axis in atopic dermatitis: exploiting insights for therapeutic strategies.Gut microbesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 1 country.
Geil R MeranaDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Laura R DwyerDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Miqdad O DhariwalaDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Antonin WeckelDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jeanmarie R GonzalezDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Joy N OkoroDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jarish N CohenDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Courtney M TamakiParnassus Flow Cytometry CoLab, University of California, San Francisco, San Francisco, 94143, USA.
Jungmin HanNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Preston TasoffBenioff Center for Microbiome Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA.
Yasmin Palacios-CalderonCity College of San Francisco, San Francisco, CA 94112, USA.
Connie W Y HaBenioff Center for Microbiome Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA.
Susan V LynchBenioff Center for Microbiome Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Julia A SegreNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Heidi H KongNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Michael G KattahDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Averil MaDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Tiffany C ScharschmidtDepartment of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: tiffany.scharschmidt@ucsf.edu.
University of California, San Francisco · USNational Institutes of Health · USCity College of San Francisco · US
Funding
Gene-Environment Interactions at the Skin SurfaceZIAHG000180 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI SEGRE, JULIA ANGELA · 2009 to 2025
$29.6MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MMicrobial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5MPREDOCTORAL TRAINING IN BIOMEDICAL SCIENCEST32GM008568 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSEL, KARL MARK · 1995 to 2019
$6.3MStudies of human microbes and potential perturbationsZIAAR041219 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$4.3MDecoding and harnessing microbial tuning of T cell responses in early lifeDP2AI144968 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHARSCHMIDT, TIFFANY CRAWFORD · 2018 to 2018
$2.4MStudies of Skin Microflora in Healthy Individuals and Atopic Dermatitis PatientsZIAAR041217 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2023
$1.2MBD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573kElucidating microbial and host mechanisms supporting early life immune imprinting by skin monocytesK99AR079554 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DHARIWALA, MIQDAD ONALI · 2021 to 2022
$178kNIAID NIH HHS DP2 AI144968NIAID NIH HHS T32 AI007334NIAID NIH HHS T32 AI060537NIAMS NIH HHS K99 AR079554NIDDK NIH HHS P30 DK063720NIGMS NIH HHS T32 GM008568NIH HHS S10 OD021822
Abstract
Resident microbes in skin and gut predominantly impact local immune cell function during homeostasis. However, colitis-associated neutrophilic skin disorders suggest possible breakdown of this compartmentalization with disease. Using a model wherein neonatal skin colonization by Staphylococcus epidermidis facilitates generation of commensal-specific tolerance and CD4
Indexed as
ColitisImmunityAnimalsInflammationMiceSkinStaphylococcus epidermidisT-Lymphocytes, Regulatorycolitiscommensalcommensal-specific T cellsCP: ImmunologyCP: Microbiologygut-skin axisinflammationintestinal immunityregulatory T cellsS. epidermidisskin immunityskin microbiome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.