Trial reportAmerican journal of respiratory and critical care medicine2022
Clinical Trial of Losartan for Pulmonary Emphysema: Pulmonary Trials Cooperative Losartan Effects on Emphysema Progression Clinical Trial.
Erratum issuedOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The Use of Computed Tomography Densitometry for the Assessment of Emphysema in Clinical Trials: A Position Paper from the Fleischner Society.American journal of respiratory and critical care medicine · 2025Pooled it
- Signal, not noise: learning to measure emphysema beyond the -950 HU threshold.European radiology · 2026Article
- New approaches to uncover COPD pathobiology and develop therapies.JCI insight · 2026Review
- Oral losartan yields subtherapeutic airway exposure compared to nebulized delivery and fails to improve mucociliary clearance in cystic fibrosis.Frontiers in pharmacology · 2026Article
- Design and Implementation of a Multi-Center Trial ofJournal of magnetic resonance imaging : JMRI · 2025Article
- Pulmonary Immunocompromise in Human Immunodeficiency Virus Disease.Clinics in chest medicine · 2025Review
- Computed Tomography Radiomics Features Predict Change in Lung Density and Rate of Emphysema Progression.Annals of the American Thoracic Society · 2025Article
- Radiomics for the Prediction of Emphysema Progression.Annals of the American Thoracic Society · 2025Article
- Does long COVID in people living with HIV resemble the functional phenotype of non-HIV individuals who had moderate or severe acute COVID-19? A retrospective cross-sectional study.Frontiers in medicine · 2025Article
- Impact of COVID-19 Vaccine Rollout on Mental Health, Social Determinants of Health, and Attitudes Among Individuals With COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Cell type-specific expression of angiotensin receptors in the human lung with implications for health, aging, and chronic disease.bioRxiv : the preprint server for biology · 2024Article
- Cardiovascular diseases or type 2 diabetes mellitus and chronic airway diseases: mutual pharmacological interferences.Therapeutic advances in chronic disease · 2023Review
- Impact of the Coronavirus Disease 2019 Pandemic on Physical and Mental Health of Patients With COPD: Results From a Longitudinal Cohort Study Conducted in the United States (2020-2021).Chronic obstructive pulmonary diseases (Miami, Fla.) · 2022Article
- Reply to Polverino and Celli.American journal of respiratory and critical care medicine · 2022Article
- Selecting the Right Patient: The Achilles Heel of COPD Clinical Trials.American journal of respiratory and critical care medicine · 2022Article
- Use of Computed Tomography Lung Densitometry as an Outcome Measure for Emphysema Progression: The Case of Losartan.American journal of respiratory and critical care medicine · 2022Article
- Pathogenesis and management of emphysema in people with HIV.Expert review of respiratory medicineReview
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
14 authors at 8 institutions in 1 country.
Robert A WiseJohns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-8353-2349
Janet T HolbrookCenter for Clinical Trials and Evidence Synthesis, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0002-0899-2345
Robert H BrownJohns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-7899-643X
Gerard J CrinerLewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Mark T DransfieldDivision of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0002-9207-1820
Jiaxian HeCenter for Clinical Trials and Evidence Synthesis, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0003-2727-6448
Robert J HendersonCenter for Clinical Trials and Evidence Synthesis, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0001-6805-269X
David A KaminskyDivision of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, Burlington, Vermont.ORCID 0000-0002-6515-8023
Robert J KanerDivision of Pulmonary Medicine, Weill Cornell School of Medicine, New York, New York.
Stephen C LazarusDivision of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-3230-0556
Barry J MakeDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colorado; and.ORCID 0000-0003-4349-8745
Meredith C McCormackJohns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-1702-3201
Enid R NeptuneJohns Hopkins University School of Medicine, Baltimore, Maryland.
Loretta G QueDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina.ORCID 0000-0001-9188-9244
Johns Hopkins University · USCornell University · USDuke University · USNational Jewish Health · USTemple University · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Vermont · US
Funding
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MDisparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2MNetwork Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)U01HL128954 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCIURBA, FRANK, WISNIEWSKI, STEPHEN R · 2015 to 2019
$17.0MEffect of Losartan on Progression of EmphysemaU01HL128951 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HOLBROOK, JANET T., WISE, ROBERT A. · 2015 to 2019
$1.8MNCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384NHLBI NIH HHS U01 HL128951NHLBI NIH HHS U01HL128951NHLBI NIH HHS U01 HL128954NHLBI NIH HHS U01HL128954
Abstract
PubMed holds no abstract for this paper.
Indexed as
EmphysemaPulmonary Disease, Chronic ObstructivePulmonary EmphysemaAgedAngiotensin Receptor AntagonistsBronchodilator AgentsDisease ProgressionFemaleForced Expiratory VolumeHumansLosartanMaleAngiotensin Receptor AntagonistsBronchodilator AgentsLosartanangiotensin receptor blockerclinical trialemphysemalosartanquantitative image analysis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.