ArticleAmerican journal of respiratory and critical care medicine2022
COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
Open access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Levels of brain-derived neurotrophic factor (BDNF) among patients with COVID-19: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- Beneficial effects of L-Arginine in patients hospitalized for COVID-19: New insights from a randomized clinical trial.Pharmacological research · 2023Trial
- T1R3 Anchors ACE2 at the Pulmonary Endothelial Cell Surface to Attenuate Vascular Injury Following SARS-CoV-2 Spike 1 Protein Exposure In Vitro.Journal of cellular and molecular medicine · 2026Article
- Heparin-binding protein and Endothelin-1 in critical COVID-19.BMC anesthesiology · 2026Article
- Nox1-Derived ROS Amplifies Calcium Entry and Enhances Pneumolysin-Induced Lung Endothelial Barrier Dysfunction in Hyperglycemia.Antioxidants (Basel, Switzerland) · 2026Article
- Translating animal models of SARS-CoV-2 infection to vascular, neurological and gastrointestinal manifestations of COVID-19.Disease models & mechanisms · 2025Review
- Variability in Arterial Stiffness and Vascular Endothelial Function After COVID-19 During 1.5 Years of Follow-Up-Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health.GeroScience · 2025Review
- The endothelial-immunothrombotic storm in viral sepsis: lessons from COVID-19.Frontiers in immunology · 2025Review
- Cellular Mechanisms of Lung Injury: Current Perspectives.Clinics in chest medicine · 2024Review
- Review
- Process-Specific Blood Biomarkers and Outcomes in COVID-19 Versus Non-COVID-19 ARDS (APEL-COVID Study): A Prospective, Observational Cohort Study.Journal of clinical medicine · 2024Article
- Association between Age-Adjusted Endothelial Activation and Stress Index and Intensive Care Unit Mortality in Patients with Severe COVID-19.Tuberculosis and respiratory diseases · 2024Article
- COVID-19 plasma induces subcellular remodelling within the pulmonary microvascular endothelium.Vascular pharmacology · 2024Article
- Damage to endothelial barriers and its contribution to long COVID.Angiogenesis · 2024Review
- Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients.Nature communications · 2024Article
- Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19.Brain communications · 2024Review
- Correlation between epicardial adipose tissue and myocardial injury in patients with COVID-19.Frontiers in physiology · 2024Article
- Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cellsFrontiers in medicine · 2024Article
- VEGFR and DPP-IV as Markers of Severe COVID-19 and Predictors of ICU Admission.International journal of molecular sciences · 2023Article
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Authors and funding
19 authors at 6 institutions in 4 countries.
Jérémie JoffreDepartment of Anesthesia and Perioperative Care, School of Medicine.
Lauren RodriguezDepartment of Microbiology and Immunology, School of Medicine.
Zachary A MatthayDivision of General Surgery, Trauma and Surgical Critical Care, Zuckerberg San Francisco General Hospital.
Elliot LloydDepartment of Anesthesia and Perioperative Care, School of Medicine.
Alexander T FieldsDivision of General Surgery, Trauma and Surgical Critical Care, Zuckerberg San Francisco General Hospital.
Roland J BaintonDepartment of Anesthesia and Perioperative Care, School of Medicine.
Philip KurienDepartment of Anesthesia and Perioperative Care, School of Medicine.
Anita SilDepartment of Microbiology and Immunology, School of Medicine.
Carolyn S CalfeeDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.
David J ErleCoLabs.ORCID 0000-0002-2171-0648
Carolyn HendricksonDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.
Matthew F KrummelImmunoX Initiative.
Charles R LangelierDivision of Infectious Disease, Department of Medicine, University of California, San Francisco, San Francisco, California; and.
Michael A MatthayDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine.
Lucy Z KornblithDivision of General Surgery, Trauma and Surgical Critical Care, Zuckerberg San Francisco General Hospital.ORCID 0000-0002-1861-9691
Judith HellmanDepartment of Anesthesia and Perioperative Care, School of Medicine.ORCID 0000-0003-2278-6625
COVID-19 Multi-Phenotyping for Effective Therapies (COMET) Consortium
COVID-19 Associated Coagulopathy, Inflammation, and Thrombosis (Co-ACIT) Study Group
San Francisco General Hospital · USCardiovascular Institute Hospital · JPAAB College · XKAdvanced ENT and Allergy · USAssociation of Perioperative Registered Nurses · USUniversity of California, San Francisco · US
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MPrecision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8MMicrobial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5MNHLBI NIH HHS R35 HL140026NIAID NIH HHS T32 AI060537NIAID NIH HHS U19 AI077439NIH HHS 3U19AI077439-13S2NIH HHS R35 HL140026
Abstract
PubMed holds no abstract for this paper.
Indexed as
COVID-19Vascular DiseasesBiomarkersEndothelial CellsHumansInflammation MediatorsLungPlasminogen Activator Inhibitor 1SARS-CoV-2Spike Glycoprotein, CoronavirusVascular Endothelial Growth Factor ABiomarkersInflammation MediatorsPlasminogen Activator Inhibitor 1Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vascular Endothelial Growth Factor Aacute respiratory distress syndromeCOVID-19endothelial permeabilitylung endothelial injury
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.