Evidence map›Paper›PMID 35649102›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2022

Machine Learning Prediction of Progression in Forced Expiratory Volume in 1 Second in the COPDGene® Study.

Adel Boueiz, Zhonghui Xu, Yale Chang, Aria Masoomi, Andrew Gregory, Sharon M Lutz, Dandi Qiao, James D Crapo, Jennifer G Dy, Edwin K Silverman and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Definitions of early COPD and predictors for disease progression: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Adel BoueizChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Zhonghui XuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Yale ChangDepartment of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts, United States.
Aria MasoomiDepartment of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts, United States.
Andrew GregoryChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Sharon M LutzDepartment of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States.
Dandi QiaoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
James D CrapoDivision of Pulmonary Medicine, Department of Medicine, National Jewish Health, Denver, Colorado, United States.
Jennifer G DyDepartment of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts, United States.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Peter J CastaldiChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
COPDGene Investigators
Northeastern University · USBrigham and Women's Hospital · USHarvard University · USPulmonary and Critical Care Associates · USHarvard Pilgrim Health Care · USNational Jewish Health · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Using Integrative Genomics To Identify and Characterize Emphysema-Associated eQTLR01HL124233 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2014 to 2024
$7.1M
Genetics of Smoke-Altered LTA4H in COPDR01HL126596 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN, CASTALDI, PETER · 2015 to 2018
$1.6M
Prospective Health Outcomes and Inflammatory Biomarkers Associated with e-Cigarette UseR01HL147326 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CASTALDI, PETER · 2019 to 2021
$1.5M
Clinical significance and genetic determinants of novel imaging measures of emphysema distribution in 9,743 smokersK08HL141601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI EL BOUEIZ, ADEL · 2018 to 2022
$853k
AstraZenecaBayer PharmaceuticalsBoehringer-IngelheimGenentechGlaxoSmithKlineNHLBI NIH HHS K08 HL141601NHLBI NIH HHS R01 HL124233NHLBI NIH HHS R01 HL126596NHLBI NIH HHS R01 HL147326NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NovartisPfizerSunovion
6 · The paper itself

Abstract

Background: The heterogeneous nature of chronic obstructive pulmonary disease (COPD) complicates the identification of the predictors of disease progression. We aimed to improve the prediction of disease progression in COPD by using machine learning and incorporating a rich dataset of phenotypic features. Methods: We included 4496 smokers with available data from their enrollment and 5-year follow-up visits in the COPD Genetic Epidemiology (COPDGene Results: Predicting the change in FEV Conclusion: Random forest, along with deep phenotyping, predicts FEV

Indexed as

5-year changes in FEV1copddisease progressionpredictionrandom forest machine learning

Identifiers

PMID35649102
PMCPMC9448009
OpenAlexW4282931019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.