ArticleScience advances2022
Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed.
- Molecular jackhammers induce intracellular calcium release and skeletal muscle contraction by vibronic-driven action.Chemical science · 2026Article
- Rotor-stator repulsion and medium-induced dephasing enhance and equalise the quantum efficiency of a fluorinated photon-only rotary motor.Nature communications · 2026Article
- Tertiary alkylamine-functionalized polyaspartamides with potent antibacterial activity.Bioactive materials · 2026Article
- Cu-doping site regulation in carbon dots for concurrent cuproptosis-like death anti-bacteria and osteogenesis of infected bone defects.Journal of nanobiotechnology · 2025Article
- Light-triggered molecular mechanotherapy of tumor using membrane-mimicking conjugated oligoelectrolytes.Science advances · 2025Article
- Dynamics of a light-driven molecular rotary motor in an optical cavity.Nature communications · 2025Article
- Article
- General strategy for boosting the performance of speed-tunable rotary molecular motors with visible light.Science advances · 2025Article
- Single Atom Engineered Antibiotics Overcome Bacterial Resistance.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Biofilm Disruption from within: Light-Activated Molecular Drill-Functionalized Polymersomes Bridge the Gap between Membrane Damage and Quorum Sensing-Mediated Cell Death.ACS biomaterials science & engineering · 2024Article
- Electrically polarized nanoscale surfaces generate reactive oxygenated and chlorinated species for deactivation of microorganisms.Science advances · 2024Article
- Carbon source competition within the wound microenvironment can significantly influence infection progression.NPJ biofilms and microbiomes · 2024Article
- Molecular jackhammers eradicate cancer cells by vibronic-driven action.Nature chemistry · 2024Article
- Transformable nano-antibiotics for mechanotherapy and immune activation against drug-resistant Gram-negative bacteria.Science advances · 2023Article
- A membrane intercalating metal-free conjugated organic photosensitizer for bacterial photodynamic inactivation.Chemical science · 2023Article
- Exploring antibiotic resistance with chemical tools.Chemical communications (Cambridge, England) · 2023Review
- An Update Review of Approaches to Multiple Action-Based Antibacterials.Antibiotics (Basel, Switzerland) · 2023Review
- Visible-Light-Activated Molecular Machines Kill Fungi by Necrosis Following Mitochondrial Dysfunction and Calcium Overload.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Bolaamphiphile Analogues of 12-bis-THA ClmSphere · 2023Article
- Researchers turn to tiny robots to fight antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic research and development pipeline have created a pressing global health crisis. Here, we report the discovery of a distinctive antibacterial therapy that uses visible (405 nanometers) light-activated synthetic molecular machines (MMs) to kill Gram-negative and Gram-positive bacteria, including methicillin-resistant
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.