ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2022
Novel separation mode of HPLC based on phase-separation multiphase flow.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 10 citations in OpenAlex.
- A Theranostic Study ofBioconjugate chemistry · 2026Article
- Direct visualization of phase-separation multiphase flow in a silica bead-packed microchannel using fluorescence microscopy.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Phase-separation multiphase flow: preliminary application to analytical chemistry.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Review
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4 authors at 1 institution in 1 country.
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Abstract
A novel separation mode for high-performance liquid chromatography (HPLC) is proposed based on phase-separation multiphase flow. A commercially available HPLC system was used with a packed-separation column of octadecyl-silica (ODS)-modified particles. Water/acetonitrile/ethyl acetate ternary mixed solutions, (a) 1:8:1, (b) 1:3:1, and (c) 16:3:1 (v/v/v), were delivered into the system as an eluent at 20 and 5 °C. The ternary mixed solution acted as a two-phase separation solution leading to phase-separation multiphase flow. The solution flowed in the column homogeneously and heterogeneously at 20 and 5 °C, respectively. 1-Naphthol (NA) and 2,6-naphthalenedisulfonic acid (NDS) were injected into the system as model analytes. At 20 °C, the analyte mixture did not separate in solutions (a) and (b) while it separated in solution (c) with the elution order of NDS followed by NA. At 5 °C, it did not separate in solution (a), while it separated in solution (b) with elution order of NA followed by NDS and solution (c) with elution order of NDS followed by NA more effectively than 20 °C. The separation behavior and elution order are possibly caused by the phase-separation multiphase flow.
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