ArticleJA clinical reports2022
Remimazolam anesthesia for transcatheter mitral valve repair in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome: a case report.
Article in JA clinical reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Perianesthetic Complications in Genetic Mitochondrial Disease: A Review of Case Reports.Paediatric anaesthesia · 2026Review
- Outcome of General Anesthesia With Remimazolam in a m.3243A>G Carrier.Anesthesia progress · 2026Article
- Reply to Commentary: Finsterer, J. Outcome of General Anesthesia With Remimazolam in a m.3243A>G Carrier. Anesthesia Progress. 2026;73(1):51. doi: 10.2344/25-0017.Anesthesia progress · 2026Article
- Remimazolam-based anesthesia with intraoperative motor evoked potential monitoring in a patient with Leigh syndrome undergoing scoliosis surgery: a case report.JA clinical reports · 2026Article
- MELAS Syndrome Presenting with Hypertrophic Cardiomyopathy and Advanced Heart Failure: A Multisystem Diagnostic Challenge.Journal of clinical medicine · 2026Article
- Anesthesia management for percutaneous mitral valve repair in a patient with mitochondrial cardiomyopathy and low cardiac function: a case report.JA clinical reports · 2024Article
- Article
- Remimazolam-Based Anesthesia in Patients with Heart Failure Due to Mitral Regurgitation and Low Left Ventricular Function: A Case Series.Medicina (Kaunas, Lithuania) · 2023Article
- Article
- General anesthesia with remimazolam for a pediatric patient with MELAS and recurrent epilepsy: a case report.JA clinical reports · 2022Article
- Assessing the anesthetic effectiveness of remimazolam in MELAS patients requires careful investigations.JA clinical reports · 2022Article
- Remimazolam: An Updated Review of a New Sedative and Anaesthetic.Drug design, development and therapy · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is characterized by cardiac depression, respiratory failure, myopathy, and anesthesia for affected patients is challenging. Although several anesthetics have been safely employed, there are no reports on remimazolam used in those patients. CASE PRESENTATION: A 47-year-old male with MELAS syndrome was diagnosed with mitral regurgitation and scheduled for transcatheter mitral valve repair under general anesthesia. Anesthesia was induced with remimazolam and remifentanil (0.3 µg/kg/min). Remimazolam was administered at 12 mg/kg/h until loss of consciousness for approximately 1 min. Anesthesia was maintained with 1.1-1.2 mg/kg/h of remimazolam and 0.1 µg/kg/min of remifentanil without circulatory collapse or severe metabolic acidosis. The tracheal tube was removed in the operating room.
conclusionRemimazolam may be a new option for anesthesia for MELAS syndrome patients with depressed heart function.
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