Evidence map›Paper›PMID 35648279›Full record

ArticleAnnals of biomedical engineering2022

Development and Characterization of a Nonelectronic Versatile Oxygenating Perfusion System for Tissue Preservation.

Daniel J Portillo, Jose Gonzalez, Carorina Villarreal, Sophia J Salazar, Anjelyka Fasci, Brandt Wearden, Jessica Oseghale, Anis Khalil, Thomas Perillo, Leslie Muenchow and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Daniel J PortilloDepartment of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.ORCID http://orcid.org/0000-0001-5208-7898
Jose GonzalezDepartment of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.
Carorina VillarrealDepartment of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.
Sophia J SalazarDepartment of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.
Anjelyka FasciDepartment of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.
Brandt WeardenDepartment of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.
Jessica OseghaleDepartment of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, USA.
Anis KhalilDepartment of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.
Thomas PerilloDepartment of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA.
Leslie MuenchowDepartment of Biology, The University of Texas at San Antonio, San Antonio, USA.
Robert De LorenzoDepartment of Emergency Medicine, UT Health San Antonio, San Antonio, USA.ORCID https://orcid.org/0000-0003-4364-9590
R Lyle HoodDepartment of Mechanical Engineering, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, USA. lyle.hood@utsa.edu.ORCID https://orcid.org/0000-0003-0478-2065
The University of Texas at San Antonio · USThe University of Texas Health Science Center at San Antonio · USUrology San Antonio · US

Funding

U.S. Department of Defense W81XWH-18-1-0640
6 · The paper itself

Abstract

Oxygenated machine perfusion of human organs has been shown to improve both preservation quality and time duration when compared to the current gold standard: static cold storage. However, existing machine perfusion devices designed for preservation and transportation of transplantable organs are too complicated and organ-specific to merit use as a solution for all organs. This work presents a novel, portable, and nonelectronic device potentially capable of delivering oxygenated machine perfusion to a variety of organs. An innovative pneumatic circuit system regulates a compressed oxygen source that cyclically inflates and deflates silicone tubes, which function as both the oxygenator and perfusion pump. Different combinations of silicone tubes in single or parallel configurations, with lengths ranging from 1.5 to 15.2 m, were evaluated at varying oxygen pressures from 27.6 to 110.3 kPa. The silicone tubes in parallel configurations produced higher peak perfusion pressures (70% increase), mean flow rates (102% increase), and oxygenation rates (268% increase) than the single silicone tubes that had equivalent total lengths. While pumping against a vascular resistance element that mimicked a kidney, the device achieved perfusion pressures (8.4-131.6 mmHg), flow rates (2.0-40.2 mL min

Indexed as

Organ PreservationTissue PreservationHumansOxygenPerfusionSiliconesOxygenSiliconesKidney preservationMachine perfusionOrgan preservationOxygenationTissue preservation

Identifiers

PMID35648279
OpenAlexW4281749793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.