ArticleThe ultrasound journal2022
Integrated lung ultrasound score for early clinical decision-making in patients with COVID-19: results and implications.
Article in The ultrasound journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06502002 (Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery), which is not on this map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery: A Randomized, Placebo-Controlled Pilot Trial
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Ten Questions on Using Lung Ultrasonography to Diagnose and Manage Pneumonia in Hospital-at-Home Model: Part III-Synchronicity and Foresight.Diagnostics (Basel, Switzerland) · 2026Review
- Article
- An interpretable machine learning tool for predicting perioperative cardiac events in patients scheduled for hip fracture surgery: insights from the multicenter LUSHIP study.Journal of anesthesia, analgesia and critical care · 2025Article
- Evaluating deep learning approaches for AI-assisted lung ultrasound diagnosis: an international multi-center and multi-scanner study.The ultrasound journal · 2025Article
- Connective Tissue Disorder-Induced Diffuse Alveolar Hemorrhage: A Comprehensive Review with an Emphasis on Airway and Respiratory Management.Life (Basel, Switzerland) · 2025Review
- Ten Questions on Using Lung Ultrasonography to Diagnose and Manage Pneumonia in Hospital-at-Home Model: Part II-Confounders and Mimickers.Diagnostics (Basel, Switzerland) · 2025Review
- Ten Questions on Using Lung Ultrasonography to Diagnose and Manage Pneumonia in the Hospital-at-Home Model: Part I-Techniques and Patterns.Diagnostics (Basel, Switzerland) · 2024Review
- Use of lung ultrasound to assess volume status and its association with physical examination in patients with chronic kidney disease.Clinical kidney journal · 2024Article
- Assessment of Pulmonary Circulation of Critically Ill Patients Based on Critical Care Ultrasound.Journal of clinical medicine · 2024Review
- A Novel Automatic Algorithm to Support Lung Ultrasound Non-Expert Physicians in Interstitial Pneumonia Evaluation: A Single-Center Study.Diagnostics (Basel, Switzerland) · 2024Article
- Echocardiographic parameters in COVID-19 patients and their association with ICU mortality: a prospective multicenter observational study.The ultrasound journal · 2023Article
- Unraveling the Predictive Potential of Rapid Scoring in Pleural Infection: A Critical Review.Cureus · 2023Review
- COVID-19 Lung Ultrasound Scores and Lessons from the Pandemic: A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
- The role of ultrasound in predicting non-invasive ventilation outcomes: a systematic review.Frontiers in medicine · 2023Article
- Usefulness and limitations of the acute respiratory distress syndrome definitions in non-intubated patients. A narrative review.Frontiers in medicine · 2023Review
- Utility of cardiac bioenzymes in predicting cardiovascular outcomes in SARS-CoV-2.World journal of virology · 2022Article
- SARS-CoV-2 and Endothelial Cells: Vascular Changes, Intussusceptive Microvascular Growth and Novel Therapeutic Windows.Biomedicines · 2022Review
- Lung Ultrasound in Adults and Children with COVID-19: From First Discoveries to Recent Advances.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesLung Ultrasound Score (LUS) identifies and monitors pneumonia by assigning increasing scores. However, it does not include parameters, such as inferior vena cava (IVC) diameter and index of collapse, diaphragmatic excursions and search for pleural and pericardial effusions. Therefore, we propose a new improved scoring system, termed "integrated" lung ultrasound score (i-LUS) which incorporates previously mentioned parameters that can help in prediction of disease severity and survival, choice of oxygenation mode/ventilation and assignment to subsequent areas of care in patients with COVID-19 pneumonia.
methodsUpon admission at the sub-intensive section of the emergency medical department (SEMD), 143 consecutively examined COVID-19 patients underwent i-LUS together with all other routine analysis. A database for anamnestic information, laboratory data, gas analysis and i-LUS parameters was created and analyzed.
resultsOf 143 enrolled patients, 59.4% were male (mean age 71 years) and 40.6% female. (mean age 79 years: p = 0.005). Patients that survived at 1 month had i-LUS score of 16, which was lower than that of non-survivors (median 20; p = 0.005). Survivors had a higher PaO2/FiO2 (median 321.5) compared to non-survivors (median 229, p < 0.001). There was a correlation between i-LUS and PaO2/FiO2 ratio (rho:-0.4452; p < 0.001), PaO2/FiO2 and survival status (rho:-0.3452; p < 0.001), as well as i-LUS score and disease outcome (rho:0.24; p = 0.005). In non-survivors, the serum values of different significant COVID indicators were severely expressed. The i-LUS score was higher (median 20) in patients who required non-invasive ventilation (NIV) than in those treated only by oxygen therapy (median 15.42; p = 0.003). The odds ratio for death outcome was 1.08 (confidence interval 1.02-1.15) for each point increased. At 1-month follow-up, 65 patients (45.5%) died and 78 (54.5%) survived. Patients admitted to the high critical ward had higher i-LUS score than those admitted to the low critical one (p < 0.003).
conclusionsi-LUS could be used as a helpful clinical tool for early decision-making in patients with COVID-19 pneumonia.
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