Evidence map›Paper›PMID 35648263›Full record

ArticleTechniques in coloproctology2022

Simplified Histologic Mucosal Healing Scheme (SHMHS) for inflammatory bowel disease: a nationwide multicenter study of performance and applicability.

A Caputo, P Parente, M Cadei, M Fassan, A Rispo, G Leoncini, G Bassotti, R Del Sordo, C Metelli, M Daperno and 3 more

Erratum issuedOpen access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Techniques in coloproctology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

A CaputoDepartment of Advanced Biomedical Sciences, University of Naples, Naples, Italy. alcap94@gmail.com.ORCID http://orcid.org/0000-0001-5139-3869
P ParentePathology Unit, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.
M CadeiInstitute of Pathology, ASST Spedali Civili, Brescia, Italy.
M FassanSurgical Pathology Unit, Department of Medicine, University of Padua, Padua, Italy.
A RispoDepartment of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
G LeonciniPathology Unit, ASST del Garda, Desenzano del Garda, Brescia, Italy.
G BassottiGastroenterology and Hepatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
R Del SordoSection of Anatomic Pathology and Histology, Department of Medicine and Surgery, Medical School, University of Perugia, Perugia, Italy.
C MetelliInstitute of Pathology, ASST Spedali Civili, Brescia, Italy.
M DapernoDivision of Gastroenterology, Ospedale Ordine Mauriziano di Torino, Turin, Italy.
A ArmuzziIBD Unit, Presidio Columbus Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
V VillanacciInstitute of Pathology, ASST Spedali Civili, Brescia, Italy.
SHMHS Study Group
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Naples Federico II · ITUniversity of Perugia · ITA. O. Ordine Mauriziano di Torino · ITCasa di Cura Villa Garda · ITCasa Sollievo della Sofferenza · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessment of mucosal healing is important for the management of patients with inflammatory bowel disease (IBD), but endoscopy can miss microscopic disease areas that may relapse. Histological assessment is informative, but no single scoring system is widely adopted. We previously proposed an eight-item histological scheme for the easy, fast reporting of disease activity in the intestine. The aim of the present study was to evaluate the performance of our Simplified Histologic Mucosal Healing Scheme (SHMHS).

methodsBetween April and May 2021 pathologists and gastroenterologists in Italy were invited to contribute to this multicenter study by providing data on single endoscopic-histological examinations for their IBD patients undergoing treatment. Disease activity was expressed using SHMHS (maximum score, 8) and either Simple Endoscopic Score for Crohn's Disease (categorized into grades 0-3) or Mayo Endoscopic Subscore (range 0-3).

resultsThirty hospitals provided data on 597 patients (291 Crohn's disease; 306 ulcerative colitis). The mean SHMHS score was 2.96 (SD = 2.42) and 66.8% of cases had active disease (score ≥ 2). The mean endoscopic score was 1.23 (SD = 1.05), with 67.8% having active disease (score ≥ 1). Histologic and endoscopic scores correlated (Spearman's ρ = 0.76), and scores for individual SHMHS items associated directly with endoscopic scores (chi-square p < 0.001, all comparisons). Between IBD types, scores for SHMHS items reflected differences in presentation, with cryptitis more common and erosions/ulcerations less common in Crohn's disease, and the distal colon more affected in ulcerative colitis.

conclusionsSHMHS captures the main histological features of IBD. Routine adoption may simplify pathologist workload while ensuring accurate reporting for clinical decision making.

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesChronic DiseaseEndoscopy, GastrointestinalHumansIntestinal MucosaSeverity of Illness IndexEndoscopic scoreHistological assessmentInflammatory bowel diseaseMucosal healing

Identifiers

PMID35648263
PMCPMC9360061
OpenAlexW4281618304

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.