Evidence map›Paper›PMID 35648220›Full record

ArticlePflugers Archiv : European journal of physiology2022

AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9

Leonie Achner, Tobias Klersy, Benedikt Fels, Tobias Reinberger, Cosima X Schmidt, Natalie Groß, Susanne Hille, Oliver J Müller, Zouhair Aherrahrou, Kristina Kusche-Vihrog and 1 more

Open access · hybridFull text read
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Modulation of arterial intima stiffness by disturbed blood flow.Experimental biology and medicine (Maywood, N.J.) · 2024
    Article
  3. Article
  4. The extracellular matrix mechanics in the vasculature.Nature cardiovascular research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Leonie Achner *Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
Tobias Klersy *Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
Benedikt FelsInstitute for Physiology, University Lübeck, Lübeck, Germany.
Tobias ReinbergerDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/, Lübeck, Germany.
Cosima X SchmidtInstitute of Neurobiology, University of Lübeck, Lübeck, Germany.
Natalie GroßInstitute for Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.
Susanne HilleDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/, Lübeck, Germany.
Oliver J MüllerDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/, Lübeck, Germany.
Zouhair AherrahrouDZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/, Lübeck, Germany.
Kristina Kusche-Vihrog *Institute for Physiology, University Lübeck, Lübeck, Germany.
Walter Raasch *Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. walter.raasch@uni-luebeck.de.
University of Lübeck · DEGerman Centre for Cardiovascular Research · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Investigating atherosclerosis and endothelial dysfunction has mainly become established in genetically modified ApoE

Indexed as

AtherosclerosisProprotein Convertase 9AnimalsCholesterolDisease Models, AnimalEndothelial CellsMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Atomic ForceTriglyceridesCholesterolProprotein Convertase 9TriglyceridesAAV-PCSK9DY mouse modelAtherosclerosisAtomic force microscopyCortical stiffnessEndothelial dysfunction

Identifiers

PMID35648220
PMCPMC9393126
OpenAlexW4281748724

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.