Evidence map›Paper›PMID 35648175›Full record

ArticleSocial psychiatry and psychiatric epidemiology2023

General and age-specific fertility rates in non-affective psychosis: population-based analysis of Scottish women.

Angus MacBeth, Paula McSkimming, Sohinee Bhattacharya, John Park, Andrew Gumley, David St Clair, Sarah J E Barry

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Angus MacBethUniversity of Edinburgh, Edinburgh, Scotland, UK. angus.macbeth@ed.ac.uk.ORCID http://orcid.org/0000-0002-0618-044X
Paula McSkimmingRobertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK.
Sohinee BhattacharyaUniversity of Aberdeen, Aberdeen, Scotland, UK.
John ParkNHS Greater Glasgow and Clyde, Glasgow, Scotland, UK.
Andrew GumleyMental Health and Wellbeing, Institute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK.
David St ClairUniversity of Aberdeen, Aberdeen, Scotland, UK.
Sarah J E BarryDepartment of Mathematics and Statistics, University of Strathclyde, Glasgow, Scotland, UK.
University of Aberdeen · GBUniversity of Glasgow · GBMRC Centre for Reproductive Health · GBNHS Greater Glasgow and Clyde · GBUniversity of Strathclyde · GB

Funding

Chief Scientist Office CGA/19/13Chief Scientist Office, Scottish Government Health and Social Care Directorate Grant CZH/4/951Medical Research Council MC_PC_MR/R01910X/1Medical Research Council MR/S035818/1NHS Research Scotland NHS Research Scotland Career Research Fellowship
6 · The paper itself

Abstract

purposeWomen diagnosed with non-affective psychosis have a lower general fertility rate (GFR) and age-specific fertility rate (ASFR) than women in the general population. Contemporary data on GFR in this group remain limited, despite substantive changes in prescribing and management. We calculated contemporary estimates of the GFR and ASFR for women diagnosed with non-affective psychosis compared with the general population of women without this diagnosis.

methodsA population-based design combined routinely collected historical maternity and psychiatric data from two representative areas of Scotland. Women were included from the NHS Grampian or Greater Glasgow and Clyde areas and were aged 15-44 between 2005 and 2013 inclusive. The 'exposed' group had a diagnosis of non-affective psychosis (ICD-10 F20-F29) and was compared to the general population of 'unexposed' women in the same geographical areas.

resultsAnnual GFR between 2005 and 2013 for women with non-affective psychosis varied from 9.6 to 21.3 live births/1000 women per year in the exposed cohort and 52.7 to 57.8 live births/1000 women per year in the unexposed cohort, a rate ratio (RR) of 0.28 [p < 0.001; 95% CI (0.24, 0.32)]. ASFR for all 5-year age groups was lower in the exposed cohort than amongst unexposed women.

conclusionWe highlight continued low fertility rates in women with a diagnosis of non-affective psychosis, despite widespread availability of prolactin-sparing atypical antipsychotics. Accurate estimation of fertility rates remains crucial in developing needs-matched perinatal care for these women. Methodological improvements using routine datasets to investigate perinatal mental health are also urgently needed.

Indexed as

Antipsychotic AgentsPsychotic DisordersBirth RateFemaleHumansPregnancyScotlandAntipsychotic AgentsAntipsychoticsFertilityPsychotic disordersSchizophreniaWomen

Identifiers

PMID35648175
PMCPMC9845143
OpenAlexW4281625074

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.