Evidence map›Paper›PMID 35648147›Full record

ArticleMolecular pharmaceutics2022

Very-Rapidly Dissolving Printlets of Isoniazid Manufactured by SLS 3D Printing: In Vitro and In Vivo Characterization.

Tahir Khuroo, Eman M Mohamed, Sathish Dharani, Canberk Kayalar, Tanil Ozkan, Mathew A Kuttolamadom, Ziyaur Rahman, Mansoor A Khan

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Rising role of 3D-printing in delivery of therapeutics for infectious disease.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tahir KhurooIrma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Reynolds Medical Sciences Building, Suite 159, College Station, Texas 77843-1114, United States.
Eman M MohamedIrma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Reynolds Medical Sciences Building, Suite 159, College Station, Texas 77843-1114, United States.
Sathish DharaniIrma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Reynolds Medical Sciences Building, Suite 159, College Station, Texas 77843-1114, United States.
Canberk KayalarIrma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Reynolds Medical Sciences Building, Suite 159, College Station, Texas 77843-1114, United States.
Tanil OzkanDover Precision Components, Woodlands, Texas 77380, United States.
Mathew A KuttolamadomDepartment of Engineering Technology & Industrial Distribution, College of Engineering, Texas A&M University, College Station, Texas 77843, United States.
Ziyaur RahmanIrma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Reynolds Medical Sciences Building, Suite 159, College Station, Texas 77843-1114, United States.
Mansoor A KhanIrma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Reynolds Medical Sciences Building, Suite 159, College Station, Texas 77843-1114, United States.ORCID 0000-0003-3649-3874

Funding

Dose Flexible Combination 3D-Printed Delivery Systems for Antiviral Therapy in ChildrenR01HD112077 · NICHD · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MANSOOR A KHAN, Ziyaur Rahman · 2023 to 2026
$2.2M
Age-appropriate flexible pediatric drug delivery systemsR56HD106612 · NICHD · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI KHAN, MANSOOR A · 2021 to 2022
$677k
NICHD NIH HHS R01 HD112077NICHD NIH HHS R56 HD106612
6 · The paper itself

Abstract

The focus of this research was to understand the effects of formulation and processing variables on the very-rapidly dissolving printlets of isoniazid (INH) manufactured by the selective laser sintering (SLS) three-dimensional (3D) printing method, and to characterize their physicochemical properties, stability, and pharmacokinetics. Fifteen printlet formulations were manufactured by varying the laser scanning speed (400-500 mm/s,

Indexed as

ExcipientsIsoniazidPrinting, Three-DimensionalSolubilityTabletsX-Ray MicrotomographyExcipientsIsoniazidTabletsisoniazidpharmacokineticsprintletsrecyclabilityselective laser sinteringstability

Identifiers

PMID35648147
PMCPMC9413616

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.