Evidence map›Paper›PMID 35647648›Full record

ArticleAntimicrobial agents and chemotherapy2022

A Two Amino Acid Duplication, L167E168, in the Ω-Loop Drastically Decreases Carbapenemase Activity of KPC-53, a Natural Class A β-Lactamase.

Alessandra Piccirilli, Sabrina Cherubini, Giuseppe Celenza, Gian Maria Rossolini, Fabrizia Brisdelli, Bernardetta Segatore, Luigi Principe, Francesco Luzzaro, Lilia Andriani, Gianfranco Amicosante and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Clinical microbiology reviews · 2023
    Review
  3. Exploring avibactam and relebactam inhibition ofAntimicrobial agents and chemotherapy · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Alessandra PiccirilliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Sabrina CherubiniDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Giuseppe CelenzaDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Gian Maria RossoliniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID 0000-0002-9386-0434
Fabrizia BrisdelliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Bernardetta SegatoreDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Luigi PrincipeClinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco, Italy.
Francesco LuzzaroClinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco, Italy.
Lilia AndrianiClinical Pathology and Microbiology Unit, Moriggia Pelascini General Hospital, Gravedona, Italy.
Gianfranco AmicosanteDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Mariagrazia PerilliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0001-7370-1455
University of L'Aquila · ITAlessandro Manzoni Hospital · ITAzienda Ospedaliero-Universitaria Careggi · ITMoriggia Pelascini Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KPC-53 enzyme is a natural KPC variant which showed a duplication of L167E168 residues in the Ω-loop structure. The

Indexed as

Amino Acidsbeta-LactamasesAnti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase InhibitorsDrug CombinationsEscherichia coliKlebsiella pneumoniaeMicrobial Sensitivity TestsAmino AcidsAnti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-LactamasescarbapenemaseDrug CombinationscarbapenemaseKPC-53serine-β-lactamase

Identifiers

PMID35647648
PMCPMC9211410
OpenAlexW4281683290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.