Evidence map›Paper›PMID 35647647›Full record

ArticleAntimicrobial agents and chemotherapy2022

High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria.

Fabio Tamaki, Fabio Fisher, Rachel Milne, Fernando Sánchez-Román Terán, Natalie Wiedemar, Karolina Wrobel, Darren Edwards, Hella Baumann, Ian H Gilbert, Beatriz Baragana and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. An OptimizedBio-protocol · 2024
    Article
  8. Article
  9. Translation inhibition efficacy does not determine thebioRxiv : the preprint server for biology · 2023
    Article
  10. Article
  11. Identification ofmSphere · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Fabio Tamaki *Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Fabio Fisher *Department of Life Sciences, Imperial College Londongrid.7445.2, London, United Kingdom.
Rachel MilneWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Fernando Sánchez-Román TeránDepartment of Life Sciences, Imperial College Londongrid.7445.2, London, United Kingdom.
Natalie WiedemarWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Karolina WrobelWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Darren EdwardsWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Hella BaumannDepartment of Life Sciences, Imperial College Londongrid.7445.2, London, United Kingdom.
Ian H GilbertWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.ORCID 0000-0002-5238-1314
Beatriz BaraganaWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Jake BaumDepartment of Life Sciences, Imperial College Londongrid.7445.2, London, United Kingdom.
Susan WyllieWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.ORCID 0000-0001-8810-5605
University of Dundee · GBImperial College London · GBUNSW Sydney · AU

Funding

Medical Research Council [P51477]Wellcome TrustWellcome Trust [100993/Z/13/Z]Wellcome Trust [105686/Z/14/Z]Wellcome Trust [203134/Z/16/Z]
6 · The paper itself

Abstract

Artemisinin-based combination therapies have been crucial in driving down the global burden of malaria, the world's largest parasitic killer. However, their efficacy is now threatened by the emergence of resistance in Southeast Asia and sub-Saharan Africa. Thus, there is a pressing need to develop new antimalarials with diverse mechanisms of action. One area of

Indexed as

AntimalarialsMalariaMalaria, FalciparumDrug DiscoveryHigh-Throughput Screening AssaysHumansPlasmodium falciparumAntimalarialsantimalarialsdrug discoveryin vitro translationmalariaPlasmodiumprotein synthesis

Identifiers

PMID35647647
PMCPMC9211397
OpenAlexW4281706658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.