Evidence map›Paper›PMID 35647645›Full record

ArticleAntimicrobial agents and chemotherapy2022

Impact of Tigecycline on C. difficile Outcomes: Case Series and Propensity-Matched Retrospective Study.

Emma C Phillips, Cirle A Warren, Jennie Z Ma, Gregory R Madden

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Management ofEClinicalMedicine · 2025
    Review
  3. Management of severe and fulminantJournal of medical microbiology · 2025
    Review
  4. Review
  5. Clinical microbiology reviews · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Emma C PhillipsUniversity of Virginiagrid.27755.32 School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0002-5427-2074
Cirle A WarrenDivision of Infectious Diseases & International Health, Department of Medicine, University of Virginiagrid.27755.32 School of Medicine, Charlottesville, Virginia, USA.
Jennie Z MaDepartment of Public Health Sciences, University of Virginiagrid.27755.32 Health System, Charlottesville, Virginia, USA.
Gregory R MaddenDivision of Infectious Diseases & International Health, Department of Medicine, University of Virginiagrid.27755.32 School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0002-5951-3156
University of Virginia · USUniversity of Virginia Health System · US

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Alanyl-glutamine supplementation of standard treatment for C. difficile infectionR01AI145322 · NIAID · UNIVERSITY OF VIRGINIA · PI WARREN, CIRLE ALCANTARA · 2020 to 2024
$4.0M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI PAPIN, JASON, WORRALL, BRADFORD B · 2019 to 2023
$3.9M
Interdisciplinary Training in Systems & Biomolecular Data ScienceT32GM145443 · NIGMS · UNIVERSITY OF VIRGINIA · PI Kevin A Janes, Jason Papin · 2022 to 2026
$1.5M
Immune profiling to stratify Clostridioides difficile infection outcomesK23AI163368 · NIAID · UNIVERSITY OF VIRGINIA · PI MADDEN, GREGORY RUSSELL · 2021 to 2025
$961k
HHS | National Institutes of Health (NIH) AI145322HHS | National Institutes of Health (NIH) K23AI163368HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR003015NCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR003015NIAID NIH HHS K23 AI163368NIAID NIH HHS R01 AI145322NIGMS NIH HHS T32 GM145443
6 · The paper itself

Abstract

This case series and propensity-matched cohort study on the use of tigecycline in Clostridioides difficile infection (CDI) evaluated the effect of tigecycline on 30-day mortality. Adjusted for ATLAS Score, hypotension, treatment time period, and serum lactate, tigecycline did not significantly improve 30-day mortality (odds ratio: 0.89; 95% confidence interval: 0.25-3.12;

Indexed as

Clostridioides difficileClostridium InfectionsTigecyclineAnti-Bacterial AgentsHumansRetrospective StudiesAnti-Bacterial AgentsTigecyclineClostridioides difficiletigecycline

Identifiers

PMID35647645
PMCPMC9211400
OpenAlexW4281698745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.