ArticleOphthalmology science2022
Nonperfusion Area and Other Vascular Metrics by Wider Field Swept-Source OCT Angiography as Biomarkers of Diabetic Retinopathy Severity.
Article in Ophthalmology science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 44 citations in OpenAlex.
- Impact of Optical Coherence Tomography Angiography Scan Protocols on Quantitative Microvascular Biomarkers in Diabetic Retinopathy.Translational vision science & technology · 2026Article
- Retinal Capillary Loss Is More Severe in the Midperiphery Than in the Macula in Eyes With Diabetic Retinopathy Compared to Healthy Eyes.Translational vision science & technology · 2026Article
- Topographical Evaluation of Neovessels in Proliferative Diabetic Retinopathy by Using a Multimodal Imaging Approach.Journal of clinical medicine · 2026Article
- Prognostic value of expanded-field OCT angiography in visual acuity outcomes for non-proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Diabetes May Modulate the Association Between Age and Optical Coherence Tomography Angiography Parameters: A Serial, Cross-Sectional Study.Journal of personalized medicine · 2026Article
- Evaluation of Vascular Biomarkers in Diabetic Retinopathy Using Ultrawide-Field Swept-Source Optical Coherence Tomography Angiography: The DRIVE Study.Investigative ophthalmology & visual science · 2026Article
- Retinal Characteristics in Eyes With Retinal Vein Occlusion Using Widefield Swept-Source Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2026Article
- Automated Nonperfusion Quantification in Diabetic Retinopathy on Ultra-Widefield Swept-Source OCT Angiography.Ophthalmology science · 2026Article
- Integration of ultra-widefield optical coherence tomography angiography images and clinical indicators for identifying early-stage diabetic retinopathy in type 2 diabetes.Frontiers in endocrinology · 2026Article
- Influence of Anti-VEGF Injections on Longitudinal Changes in Vascular Metrics Measured by OCTA in Age Related Macular Degeneration: A Retrospective Real-World Study.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Deep learning for retinal non-perfusion and foveal avascular zone analysis in wide-field OCTA in diabetic retinopathy.Scientific reports · 2025Article
- Flow and ischemic changes in retina and choroid across diabetic retinopathy spectrum: a SS-OCTA study.Eye (London, England) · 2025Observational
- Reduced retinal microvascular density in women with coronary microvascular dysfunction: A pilot study.American heart journal plus : cardiology research and practice · 2025Article
- Clinical and imaging characteristics associated with foveal neovascularization in proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Observational
- Comparison of widefield swept-source optical coherence tomography angiography and ultra-widefield fluorescein angiography in the detection of non-perfusion areas in diabetic retinopathy.Frontiers in endocrinology · 2025Article
- The novel antidiabetic medications on diabetic retinopathy: relevant molecular mechanisms, advancing diagnostic innovations, and therapeutic implications.Frontiers in medicine · 2025Review
- The Effects of Anti-Vascular Endothelial Growth Factor Loading Injections on Retinal Microvasculature in Diabetic Macular Edema.Translational vision science & technology · 2024Article
- Longitudinal Assessment of Intraretinal Microvascular Abnormalities in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2024Article
- Multi-Plexus Nonperfusion Area Segmentation in Widefield OCT Angiography Using a Deep Convolutional Neural Network.Translational vision science & technology · 2024Article
- Widefield swept-source optical coherence tomography angiography metrics associated with neovascular glaucoma in patients with proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 2 countries.
Funding
Abstract
Purpose: To study the wider field swept-source optical coherence tomography angiography (WF SS-OCTA) metrics, especially non-perfusion area (NPA), in the diagnosing and staging of DR. Design: Cross-sectional observational study (November 2018-September 2020). Participants: 473 eyes of 286 patients (69 eyes of 49 control patients and 404 eyes of 237 diabetic patients). Methods: We imaged using 6mm×6mm and 12mm×12mm angiograms on WF SS-OCTA. Images were analyzed using the ARI Network and FIJI ImageJ. Mixed effects multiple regression models and receiver operator characteristic analysis was used for statistical analyses. Main Outcome Measures: Quantitative metrics such as vessel density (VD); vessel skeletonized density (VSD); foveal avascular zone (FAZ) area, circularity, and perimeter; and NPA in DR and their relative performance for its diagnosis and grading. Results: Among patients with diabetes (median age 59 years), 51 eyes had no DR, 185 eyes (88 mild, 97 moderate-severe) had non-proliferative DR (NPDR); and 168 eyes had proliferative DR (PDR). Trend analysis revealed a progressive decline in superficial capillary plexus (SCP) VD and VSD, and increased NPA with increasing DR severity. Additionally, there was a significant reduction in deep capillary plexus (DCP) VD and VSD in early DR (mild NPDR), but the progressive reduction in advanced DR stages was not significant. NPA was the best parameter to diagnose DR (AUC:0.96), whereas all parameters combined on both angiograms efficiently diagnosed (AUC:0.97) and differentiated between DR stages (AUC range:0.83-0.97). The presence of diabetic macular edema was associated with reduced SCP and DCP VD and VSD within mild NPDR eyes, whereas an increased VD and VSD in SCP among moderate-severe NPDR group. Conclusions: Our work highlights the importance of NPA, which can be more readily and easily measured with WF SS-OCTA compared to fluorescein angiography. It is additionally quick and non-invasive, and hence can be an important adjunct for DR diagnosis and management. In our study, a combination of all OCTA metrics on both 6mm×6mm and 12mm×12mm angiograms had the best diagnostic accuracy for DR and its severity. Further longitudinal studies are needed to assess NPA as a biomarker for progression or regression of DR severity.
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