Evidence map›Paper›PMID 35647566›Full record

ArticleJVS-vascular science2022

Modulation of interleukin-6 and its effect on late vein wall injury in a stasis mouse model of deep vein thrombosis.

Abigail R Dowling, Catherine E Luke, Qing Cai, Antonio M Pellerito, Andrea T Obi, Peter K Henke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JVS-vascular science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Abigail R DowlingConrad Jobst Vascular Surgery Research Laboratories, Department of Surgery, College of Medicine, University of Michigan, Ann Arbor, MI.
Catherine E LukeConrad Jobst Vascular Surgery Research Laboratories, Department of Surgery, College of Medicine, University of Michigan, Ann Arbor, MI.
Qing CaiConrad Jobst Vascular Surgery Research Laboratories, Department of Surgery, College of Medicine, University of Michigan, Ann Arbor, MI.
Antonio M PelleritoConrad Jobst Vascular Surgery Research Laboratories, Department of Surgery, College of Medicine, University of Michigan, Ann Arbor, MI.
Andrea T ObiConrad Jobst Vascular Surgery Research Laboratories, Department of Surgery, College of Medicine, University of Michigan, Ann Arbor, MI.
Peter K HenkeConrad Jobst Vascular Surgery Research Laboratories, Department of Surgery, College of Medicine, University of Michigan, Ann Arbor, MI.
University of Michigan–Ann Arbor · US

Funding

The Monocyte/Macrophage Role in Experimental Deep Vein Thrombosis Resolution and Vein Wall InjuryR01HL144550 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K · 2020 to 2023
$2.2M
The Role of IL-6 in Experimental Post Thrombotic SyndromeR01HL132988 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K · 2016 to 2019
$1.9M
NHLBI NIH HHS R01 HL132988NHLBI NIH HHS R01 HL144550
6 · The paper itself

Abstract

Objective: Deep vein thrombosis (DVT) and its sequela, post-thrombotic syndrome (PTS), remain a clinically significant problem. Interleukin-6 (IL-6) is a proinflammatory cytokine that is elevated in patients who develop PTS. We hypothesized that genetic deletion of IL-6 and the use of anti-IL-6 pharmacologic agents would be associated with decreased late vein wall injury. Methods: Wild-type C57BL/6J (WT) and IL-6 Results: Less fibrosis but no increase in luminal endothelialization was found in IL-6 Conclusions: IL-6 genetic deletion was associated with less fibrotic vein wall injury at a late time point, consistent with the PTS timeframe. However, neither the standard of care LMWH nor two available anti-IL-6 agents showed antifibrotic biologic effects in this model.

Indexed as

Deep vein thrombosisInterleukin-6LovenoxLow-molecular-weight heparinVein wall remodelingVenous thrombosis

Identifiers

PMID35647566
PMCPMC9133633
OpenAlexW4224221980

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.