Evidence map›Paper›PMID 35647563›Full record

ArticleHGG advances2022

Accounting for population structure in genetic studies of cystic fibrosis.

Hanley Kingston, Adrienne M Stilp, William Gordon, Jai Broome, Stephanie M Gogarten, Hua Ling, John Barnard, Shannon Dugan-Perez, Patrick T Ellinor, Stacey Gabriel and 17 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HGG advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00037765 (Gene Modifiers of Cystic Fibrosis Lung Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00037765 active not recruitingnot on this map

Gene Modifiers of Cystic Fibrosis Lung Disease

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2001 to 2027Enrolled600ConditionsCystic Fibrosis, Lung Diseases
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Annals of the American Thoracic Society · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 11 institutions in 1 country.

Hanley KingstonInstitute for Public Health Genetics, University of Washington, Seattle, WA 98195, USA.
Adrienne M StilpDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
William GordonDepartment of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, WA 98195, USA.
Jai BroomeDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Hua LingDepartment of Genetic Medicine, Center for Inherited Disease Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
John BarnardDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Shannon Dugan-PerezHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Patrick T EllinorCardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02124, USA.
Stacey GabrielBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Soren GermerNew York Genome Center, New York, NY 10013, USA.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Namrata GuptaBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Albert V SmithDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Michael C ZodyNew York Genome Center, New York, NY 10013, USA.
Cystic Fibrosis Genome Project
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Scott M BlackmanDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Garry CuttingMcKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Michael R KnowlesMarsico Lung Institute/UNC CF Research Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Yi-Hui ZhouDepartment of Biological Sciences, North Carolina State University, Raleigh, NC 27797, USA.
Margaret RosenfeldCenter for Clinical and Translational Research, Seattle Children's Hospital, Seattle, WA 98105, USA.
Ronald L GibsonCenter for Clinical and Translational Research, Seattle Children's Hospital, Seattle, WA 98105, USA.
Michael BamshadDepartment of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, WA 98195, USA.
Alison FohnerInstitute for Public Health Genetics, University of Washington, Seattle, WA 98195, USA.
Elizabeth E BlueInstitute for Public Health Genetics, University of Washington, Seattle, WA 98195, USA.
University of Washington · USBroad Institute · USJohns Hopkins University · USBaylor College of Medicine · USNew York Genome Center · USSeattle Children's Hospital · USUniversity of North Carolina at Chapel Hill · USCleveland Clinic Lerner College of Medicine · USNorth Carolina State University · USUniversity of Michigan · USUniversity of Washington Medical Center · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
Predoctoral Research Training in Statistical Genetics Administrative SupplementT32GM081062 · NIGMS · UNIVERSITY OF WASHINGTON · PI THORNTON, TIMOTHY ALVIN · 2007 to 2021
$2.4M
Identification of genetic modifiers of Alzheimer's disease in multiethnic cohortsR01AG059737 · NIA · UNIVERSITY OF WASHINGTON · PI BLUE, ELIZABETH ELOYCE · 2018 to 2022
$1.9M
NIA NIH HHS R01 AG059737NIDDK NIH HHS P30 DK089507NIGMS NIH HHS T32 GM081062
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CFTR F508delgenome-wide association studypopulation structure

Identifiers

PMID35647563
PMCPMC9136666
OpenAlexW4280534872

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.