Evidence map›Paper›PMID 35647551›Full record

ArticleRSC medicinal chemistry2022

RpoN-Based stapled peptides with improved DNA binding suppress

André R Paquette, Sterling R Payne, Geoffrey A McKay, Jordan T Brazeau-Henrie, Micheal G Darnowski, Anitha Kammili, Federico Bernal, Thien-Fah Mah, Samantha Gruenheid, Dao Nguyen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

André R PaquetteDepartment of Chemistry and Biomolecular Sciences, University of Ottawa Ottawa ON K1N 6N5 Canada cboddy@uottawa.ca.
Sterling R PayneLaboratory of Protein Dynamics and Signaling, National Cancer Institute, National Institutes of Health Frederick MD 21702 USA.
Geoffrey A McKayMeakins-Christie Laboratories, Research Institute of the McGill University Health Centre Montreal Quebec H4A 3J1 Canada.
Jordan T Brazeau-HenrieDepartment of Chemistry and Biomolecular Sciences, University of Ottawa Ottawa ON K1N 6N5 Canada cboddy@uottawa.ca.
Micheal G DarnowskiDepartment of Chemistry and Biomolecular Sciences, University of Ottawa Ottawa ON K1N 6N5 Canada cboddy@uottawa.ca.
Anitha KammiliDepartment of Chemistry and Biomolecular Sciences, University of Ottawa Ottawa ON K1N 6N5 Canada cboddy@uottawa.ca.ORCID https://orcid.org/0000-0003-4909-205X
Federico BernalLaboratory of Protein Dynamics and Signaling, National Cancer Institute, National Institutes of Health Frederick MD 21702 USA.
Thien-Fah MahDepartment of Biochemistry, Microbiology, and Immunology, University of Ottawa Ottawa ON K1H 8M5 Canada.
Samantha GruenheidComplex Traits Group, McGill University Montreal Quebec H3G 0B1 Canada.
Dao NguyenMeakins-Christie Laboratories, Research Institute of the McGill University Health Centre Montreal Quebec H4A 3J1 Canada.
Christopher N BoddyDepartment of Chemistry and Biomolecular Sciences, University of Ottawa Ottawa ON K1N 6N5 Canada cboddy@uottawa.ca.ORCID https://orcid.org/0000-0002-3259-3184

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stapled peptides have the ability to mimic α-helices involved in protein binding and have proved to be effective pharmacological agents for disrupting protein-protein interactions. DNA-binding proteins such as transcription factors bind their cognate DNA sequences

Identifiers

PMID35647551
PMCPMC9020619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.