Evidence map›Paper›PMID 35647524›Full record

ArticleCurrent research in pharmacology and drug discovery2022

Low-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitis.

Brenda Fernanda Moreira Castro, Carolina Nunes da Silva, Lídia Pereira Barbosa Cordeiro, Sarah Pereira de Freitas Cenachi, Daniel Vitor Vasconcelos-Santos, Renes Resende Machado, Luiz Guilherme Dias Heneine, Luciana Maria Silva, Armando Silva-Cunha, Silvia Ligório Fialho

Open access · goldAbstract read
In one paragraph

Article in Current research in pharmacology and drug discovery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Brenda Fernanda Moreira CastroFaculty of Pharmacy, Federal University of Minas Gerais, 6627 Presidente Antônio Carlos Avenue, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Carolina Nunes da SilvaFaculty of Pharmacy, Federal University of Minas Gerais, 6627 Presidente Antônio Carlos Avenue, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Lídia Pereira Barbosa CordeiroDepartment of Chemistry, Federal University of Minas Gerais, 6627 Presidente Antônio Carlos Avenue, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Sarah Pereira de Freitas CenachiFaculty of Medicine, Federal University of Minas Gerais, 190 Professor Alfredo Balena Avenue, Santa Efigenia, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Daniel Vitor Vasconcelos-SantosFaculty of Medicine, Federal University of Minas Gerais, 190 Professor Alfredo Balena Avenue, Santa Efigenia, Belo Horizonte, Minas Gerais, 30130-100, Brazil.
Renes Resende MachadoFaculty of Pharmacy, Federal University of Minas Gerais, 6627 Presidente Antônio Carlos Avenue, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Luiz Guilherme Dias HeneineLaboratory of Immunology, Ezequiel Dias Foundation, 80, Conde Pereira Carneiro Street, Gameleira, Belo Horizonte, Minas Gerais, 30510-010, Brazil.
Luciana Maria SilvaLaboratory of Cell Biology, Ezequiel Dias Foundation, 80, Conde Pereira Carneiro Street, Gameleira, Belo Horizonte, Minas Gerais, 30510-010, Brazil.
Armando Silva-CunhaFaculty of Pharmacy, Federal University of Minas Gerais, 6627 Presidente Antônio Carlos Avenue, Pampulha, Belo Horizonte, Minas Gerais, 31270-901, Brazil.
Silvia Ligório FialhoPharmaceutical Research and Development, Ezequiel Dias Foundation, 80, Conde Pereira Carneiro Street, Gameleira, Belo Horizonte, Minas Gerais, 30510-010, Brazil.
Universidade Federal de Minas Gerais · BREzequiel Dias Foundation · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uveitis is a group of sight-threatening ocular inflammatory disorders, whose mainstay of therapy is associated with severe adverse events, prompting the investigation of alternative treatments. The peptide melittin (MEL) is the major component of

Indexed as

AntiangiogenicEyeInflammationMelittinPeptideUveitis

Identifiers

PMID35647524
PMCPMC9130091
OpenAlexW4280629908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.