Evidence map›Paper›PMID 35647308›Full record

ArticleEuropean stroke journal2022

European Stroke Organisation guidelines on stroke in women: Management of menopause, pregnancy and postpartum.

Christine Kremer, Zuzana Gdovinova, Yannick Bejot, Mirjam R Heldner, Susanna Zuurbier, Silke Walter, Avtar Lal, Corina Epple, Svetlana Lorenzano, Marie-Luise Mono and 5 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in European stroke journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Antiphospholipid syndrome and pregnancy-a hematologic perspective.Research and practice in thrombosis and haemostasis · 2026
    Article
  8. Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  9. Article
  10. Observational
  11. Article
  12. Do stroke services still show sex differences? A multicenter study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  13. Hormones and thrombosis: the dark side of the moon.Blood transfusion = Trasfusione del sangue · 2024
    Review
  14. Article
  15. Sex and hypertensive organ damage: stroke.Journal of human hypertension · 2023
    Review
  16. Observational
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 14 institutions in 12 countries.

Christine KremerNeurology Department, Clinical Sciences Lund University, Skåne University Hospital, Malmö, Sweden.ORCID https://orcid.org/0000-0002-5739-6523
Zuzana GdovinovaNeurology Department, Faculty of Medicine, Pavol Jozef Safarik University Košice, Košice, Slovakia.
Yannick BejotDijon Stroke Registry, Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases (PEC2), University of Burgundy, University Hospital of Dijon, Dijon, France.
Mirjam R HeldnerDepartment of Neurology, Inselspital, University Hospital and University of Bern, Bern, Switzerland.
Susanna ZuurbierDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Silke WalterDepartment of Neurology, Saarland University, Homburg, Germany.ORCID https://orcid.org/0000-0002-1176-2911
Avtar LalEuropean Stroke Organisation (ESO), Basel, Switzerland.
Corina EppleDepartment of Neurology, Klinikum Hanau, Hanau, Germany.
Svetlana LorenzanoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-7100-1778
Marie-Luise MonoDepartment of Neurology, Municipal Hospital Waid und Triemli, Zürich, University Hospital and University of Bern, Bern Switzerland.
Theodore Karapanayiotides2nd Department of Neurology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kailash KrishnanStroke, Department of Acute Medicine, Queens Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.ORCID https://orcid.org/0000-0002-6486-3783
Dejana JovanovicDepartment of Emergency Neurology, Neurology Clinic, Medical Faculty, University Clinical Center of Serbia, University of Belgrade, Belgrade, Serbia.
Jesse DawsonInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.ORCID https://orcid.org/0000-0001-7532-2475
Valeria CasoStroke Unit, Santa Maria della Misericordia Hospital, University of Perugia Perugia, Italy.
University of Bern · CHAmsterdam University Medical Centers · NLAristotle University of Thessaloniki · GREuropean CanCer Organisation · BEKlinikum Hanau · DELund University · SENottingham University Hospitals NHS Trust · GBSaarland University · DESapienza University of Rome · ITUniversité de Bourgogne · FRUniversity of Belgrade · RSUniversity of Glasgow · GBUniversity of Pavol Jozef Šafárik · SKUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy, postpartum and menopause are regarded as periods women are more vulnerable to ischaemic events. There are conflicting results regarding stroke risk and hormone replacement therapy (HRT) during menopause. Stroke in pregnancy is generally increasing with serious consequences for mother and child; therefore, recommendations for acute treatment with intravenous thrombolysis (IVT) and/or mechanical thrombectomy (MT) are needed. The aim of this guideline is to support and guide clinicians in treatment decisions in stroke in women. Following the "Grading of Recommendations and Assessment, Development and Evaluation (GRADE)" approach, the guidelines were developed according to the European Stroke Organisation (ESO) Standard Operating Procedure. Systematic reviews and metanalyses were performed. Based on available evidence, recommendations were provided. Where there was a lack of evidence, an expert consensus statement was given. Low quality of evidence was found to suggest against the use of HRT to reduce the risk of stroke (ischaemic and haemorrhagic) in postmenopausal women. No data was available on the outcome of women with stroke when treated with HRT. No sufficient evidence was found to provide recommendations for treatment with IVT or MT during pregnancy, postpartum and menstruation. The majority of members suggested that pregnant women can be treated with IVT after assessing the benefit/risk profile on an individual basis, all members suggested treatment with IVT during postpartum and menstruation. All members suggested treatment with MT during pregnancy. The guidelines highlight the need to identify evidence for stroke prevention and acute treatment in women in more vulnerable periods of their lifetime to generate reliable data for future guidelines.

Indexed as

guidelinesmenopausepostpartumpregnancyStrokewomen

Identifiers

PMID35647308
PMCPMC9134774
OpenAlexW4221038064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.