ArticleACS central science2022
Edible Matrix Code with Photogenic Silk Proteins.
Article in ACS central science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- AI-enabled label free monitoring of TGFβ1-induced remodeling in iPSC-derived alveolar organoids.Materials today. Bio · 2026Article
- The structure and extraction of silk fibroin and its applications in fruit and vegetable preservation: a review.Food chemistry: X · 2026Review
- Phosphorescent supramolecular systems for medicine anticounterfeiting.Nature communications · 2026Article
- A probabilistic detection-based approach to skin and freckle segmentation.Scientific reports · 2025Article
- Nanoseed-based physically unclonable function for on-demand encryption.Science advances · 2025Article
- Machine Learning-Driven Innovations in Microfluidics.Biosensors · 2024Review
- Excitation-wavelength-dependent persistent luminescence from single-component nonstoichiometric CaGaLight, science & applications · 2024Article
- Biocompatible optical physically unclonable function hydrogel microparticles for on-dose authentication.Heliyon · 2024Article
- Heteronanostructured Field-Effect Transistors for Enhancing Entropy and Parameter Space in Electrical Unclonable Primitives.ACS nano · 2024Article
- Advances in machine learning-enhanced nanozymes.Frontiers in chemistry · 2024Review
- Food-Grade Physically Unclonable Functions.ACS applied materials & interfaces · 2023Article
- Drug classification with a spectral barcode obtained with a smartphone Raman spectrometer.Nature communications · 2023Article
- Medicine Anticounterfeiting Based on an Edible Matrix Code.ACS central science · 2022Article
- Nanozyme-based colorimetric biosensor with a systemic quantification algorithm for noninvasive glucose monitoring.Theranostics · 2022Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Counterfeit medicines are a healthcare security problem, posing not only a direct threat to patient safety and public health but also causing heavy economic losses. Current anticounterfeiting methods are limited due to the toxicity of the constituent materials and the focus of secondary packaging level protections. We introduce an edible, imperceptible, and scalable matrix code of information representation and data storage for pharmaceutical products. This matrix code is digestible as it is composed of silk fibroin genetically encoded with fluorescent proteins produced by ecofriendly, sustainable silkworm farming. Three distinct fluorescence emission colors are incorporated into a multidimensional parameter space with a variable encoding capacity in a format of matrix arrays. This code is smartphone-readable to extract a digitized security key augmented by a deep neural network for overcoming fabrication imperfections and a cryptographic hash function for enhanced security. The biocompatibility, photostability, thermal stability, long-term reliability, and low bit error ratio of the code support the immediate feasibility for dosage-level anticounterfeit measures and authentication features. The edible code affixed to each medicine can serve as serialization, track and trace, and authentication at the dosage level, empowering every patient to play a role in combating illicit pharmaceuticals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.