ArticleFrontiers in veterinary science2022
Effects of Glycyrrhiza Polysaccharides on Chickens' Intestinal Health and Homeostasis.
Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Integrated Transcriptomic and Proteomic Analyses Reveal the Effects and Mechanisms of Glycyrrhiza Polysaccharides in Alleviating Immune Stress in Broilers.Animals : an open access journal from MDPI · 2026Article
- Effects of Plant Polysaccharides on Growth Performance, Blood Biochemical Indices, Intestinal Antioxidant and Enzyme Activities, and Microbial Diversity in Early-Weaned Squabs.Animals : an open access journal from MDPI · 2026Article
- Food and Medicine Homology Substances as Potential Modulators of the Gut-Muscle Axis in Animal Meat Quality: A Review.Foods (Basel, Switzerland) · 2026Review
- Sustainable antibiotic reduction in poultry production with Pulsatilla saponins and herbal supplementation.Poultry science · 2026Article
- Article
- Effects of DifferentMicroorganisms · 2025Article
- Immunomodulation ofFoods (Basel, Switzerland) · 2025Article
- Effect ofFrontiers in veterinary science · 2025Article
- Article
- A Comparison of the Cecal Microbiota between the Infection and Recovery Periods in Chickens with Different Susceptibilities toAnimals : an open access journal from MDPI · 2024Article
- Licorice Extract Supplementation Benefits Growth Performance, Blood Biochemistry and Hormones, Immune Antioxidant Status, Hindgut Fecal Microbial Community, and Metabolism in Beef Cattle.Veterinary sciences · 2024Article
- Effects of Crude Extract ofAntioxidants (Basel, Switzerland) · 2024Article
- Effects of Spinach Extract and Licorice Extract on Growth Performance, Antioxidant Capacity, and Gut Microbiota in Weaned Piglets.Animals : an open access journal from MDPI · 2024Article
- Unraveling the web of defense: the crucial role of polysaccharides in immunity.Frontiers in immunology · 2024Review
- Fingerprint profiling for quality evaluation and the related biological activity analysis of polysaccharides from Liuweizhiji Gegen-Sangshen beverage.Frontiers in nutrition · 2024Article
- Article
- Effect of supplementation withFrontiers in veterinary science · 2024Article
- Structure of a new glycyrrhiza polysaccharide and its immunomodulatory activity.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The overuse of antibiotics in poultry farming causes the accumulation of drug residue in animals' bodies and the occurrence of antibiotic-resistant bacteria, which not only compromise animals' health but ultimately endanger human health. Thus, there is an urgent need for a novel poultry feed additive to substitute for excessive antibiotics. Glycyrrhiza polysaccharides (GPS) derived from Chinese licorice have shown promising immunomodulatory effects in previous studies. The present study investigated the pharmacological effects of GPS on poultry intestines to assess whether it can be used as a feed additive. The results show that GPS can increase production of sIgA, promote the secretion activity of goblet cells, alter the gut microbial composition and lead to changes in short-chain fatty acids. GPS also elevated both Th1 and Th2 immune responses by facilitating the expression of IL-2, IL-4, IL-1β, and IFN-γ while increasing the proportion of both CD4+ and CD8+ cells in the intestine. Moreover, the results of 16S rRNA gene sequencing showed that GPS could significantly change intestinal microbiota composition in the intestine, evidenced by the increased proportion of Bacteroides, Butyricicoccus and Eisenbergiella, as well as a decreased portion of Erysipelatoclostridium, leading to a healthier intestinal microbiota composition for the host. Taken together, it can be concluded that GPS is safe to use as a novel feed additive that can be used as an alternative to prophylactic antibiotics in poultry feeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.