SynthesisFrontiers in cardiovascular medicine2022
Association of Depression, Antidepressants With Atrial Fibrillation Risk: A Systemic Review and Meta-Analysis.
Synthesis in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Depression and anxiety disorders in patients with atrial fibrillation undergoing a pulmonary vein isolation: A systematic literature review and meta-analysis.Scientific reports · 2026Pooled it
- Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.Translational psychiatry · 2025Pooled it
- Mental Health Across the Atrial Fibrillation Continuum: Mechanisms, Outcomes, and Clinical Implications.Life (Basel, Switzerland) · 2026Review
- A bidirectional relationship between atrial fibrillation and depression: epidemiology, mechanisms, and clinical implications.Frontiers in psychiatry · 2026Review
- The impact of the TyG index and psychosocial factors on depression in elderly non-diabetic patients with atrial fibrillation.Frontiers in psychiatry · 2026Article
- Association of healthy lifestyle and the incidence of atrial fibrillation in senior adults: a prospective cohort study.BMC geriatrics · 2025Article
- Depression in Cardiac Patients Is a Major Cardiovascular Event Risk Factor: A 12-Month Observational Study.Journal of clinical medicine · 2024Article
- Associations between daytime napping, sleep duration, and depression and 15 cardiovascular diseases: a Mendelian randomization study.Cardiovascular diagnosis and therapy · 2024Article
- Associations of Depression, Antidepressants with Atrial Fibrillation Risk in HFpEF Patients.Reviews in cardiovascular medicine · 2024Article
- Neuroticism and the Risk of Atrial Fibrillation: An Observational Epidemiologic and Mendelian Randomization Study.JACC. Asia · 2024Article
- Drug-drug-interactions in patients with atrial fibrillation admitted to the emergency department.Frontiers in pharmacology · 2024Article
- Major depression disorder may causally associate with the increased atrial fibrillation risk: evidence from two-sample mendelian randomization analyses.BMC medical genomics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Depression is a possible influence factor for the increased risk of incident atrial fibrillation (AF). Although several investigations have assessed their association, the results are still controversial. Therefore, we conducted a meta-analysis to evaluate the association between depression or using antidepressants and AF. Methods: We systemically performed the literature retrieval from two electronic databases PubMed and EMBASE until March 2022 to extract relevant data. The hazard ratios (HRs) and odds ratios (OR) from included studies with 95% confidence intervals (CIs) were adjusted into the risk ratio (RR) and pooled by using the random-effects model. Results: Totally 9 studies about the associations between depression or antidepressants and incident AF risk were included in this meta-analysis. Among them, 5 studies specifically analyzed the impact of antidepressants on the risk of AF. The outcomes of our analysis indicated that depression or depressive symptoms could increase AF risk (RR = 1.15, 95% CI, 1.03-1.27, Conclusions: Based on existing investigations, both depression and the use of antidepressants are closely related to the increase of incident AF risk.
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