Evidence map›Paper›PMID 35646970›Full record

SynthesisFrontiers in medicine2022

Arterial Stiffness and Adult Onset Vasculitis: A Systematic Review.

Alberto Lo Gullo, Clemente Giuffrida, Carmela Morace, Giovanni Squadrito, Paola Magnano San Lio, Luisa Ricciardi, Carlo Salvarani, Giuseppe Mandraffino

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Immunological Markers Associated with Skin Manifestations of EGPA.International journal of molecular sciences · 2025
    Observational
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Alberto Lo GulloRheumatology Unit, Department of Medicine, ARNAS Garibaldi, Catania, Italy.
Clemente GiuffridaEmergency Unit, Department of Emergency Urgency Unit, IRCCS Neurolesi Bonino Pulejo - Piemonte, Messina, Italy.
Carmela MoraceInternal Medicine Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Giovanni SquadritoInternal Medicine Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Paola Magnano San LioDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Luisa RicciardiAllergy and Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Carlo SalvaraniRheumatology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy AUSL-IRCCS, Reggio Emilia, Italy.
Giuseppe MandraffinoInternal Medicine Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
University of Messina · ITCentro Neurolesi Bonino Pulejo · ITOspedale Garibaldi · ITUniversity of Catania · ITUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammation represents the cornerstone of the raised cardiovascular (CV) risk in patients with inflammatory rheumatic diseases (IRD), including vasculitis. Standardized mortality ratios in these patients are higher as compared to the general population, and the excess of premature mortality is due to early atherosclerotic events. Thus, IRD patients need appropriate CV risk assessment and management according to this CV disease (CVD) burden. Adequate control of CV risk is still lacking in usual care, but early diagnosis of silent and subclinical CVD is crucial to improve the long-term prognosis of these patients. Increased arterial stiffness may provide a pathophysiological link between inflammation and increased cardiovascular risk. Several noninvasive methods are now available to estimate artery stiffness in the clinical setting, including pulse wave velocity assessment. The independent predictive value of arterial stiffness for cardiovascular events has been demonstrated in general as well as in selected populations, and reference values adjusted for age and blood pressure have been suggested. Thus, arterial stiffness is an interesting biomarker for cardiovascular risk stratification. This systematic review summarizes the additional value that PWV measurement can provide in the setting of vasculitis, with a focus in the different clinical stages and CV risk prevention. This systematic review is registered with registration number: Prospero CRD42021259603.

Indexed as

ANCA vasculitisarterial stiffnessatherosclerosisBehcet diseaseinflammationTakayasu arteritisvasculitis

Identifiers

PMID35646970
PMCPMC9133451
OpenAlexW4280566584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.