Evidence map›Paper›PMID 35646902›Full record

ArticleFrontiers in cell and developmental biology2022

Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN.

Li Ding, Kaely Roeck, Cheng Zhang, Brooke Zidek, Esther Rodman, Yasmin Hernandez-Barco, Jin-San Zhang, William Bamlet, Ann Oberg, Lizhi Zhang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. GSK3βGut · 2026
    Article
  2. Article
  3. Article
  4. Glycogen Synthase Kinase 3β: A True Foe in Pancreatic Cancer.International journal of molecular sciences · 2022
    Review
  5. Modern aspects of the management of pancreatic intraductal papillary mucinous neoplasms: a narrative review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Li DingDivision of Oncology Research, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Kaely RoeckDivision of Oncology Research, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Cheng ZhangDepartment of Molecular and Experimental Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Brooke ZidekDivision of Oncology Research, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Esther RodmanDivision of Oncology Research, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Yasmin Hernandez-BarcoCenter for Cancer Research, Harvard Medical School, Boston, MA, United States.
Jin-San ZhangDivision of Oncology Research, College of Medicine, Mayo Clinic, Rochester, MN, United States.
William BamletDepartment of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Ann ObergDepartment of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Lizhi ZhangDepartment of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Nabeel BardeesyCenter for Cancer Research, Harvard Medical School, Boston, MA, United States.
Hu LiDepartment of Molecular and Experimental Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Daniel BilladeauDivision of Oncology Research, College of Medicine, Mayo Clinic, Rochester, MN, United States.
Mayo Clinic · USCenter for Cancer Research · US

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Tissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2018
$32.7M
Role of Vav1 protooncogene in pancreatic cancerP20CA102701 · NCI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI PETERSEN, GLORIA M. · 2003 to 2003
$1.5M
NCI NIH HHS P20 CA102701NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA102701
6 · The paper itself

Abstract

Glycogen synthase kinase-3β (GSK-3β) is a downstream target of oncogenic KRas and can accumulate in the nucleus in pancreatic ductal adenocarcinoma (PDA). To determine the interplay between oncogenic KRas and nuclear GSK-3β in PDA development, we generated Lox-STOP-Lox (LSL) nuclear-targeted GSK-3β animals and crossed them with LSL-KRas

Indexed as

AQP5GSK-3βintraductal papillary mucinous neoplasmKRASpancreatic adenocarcinomaprogenitor cell

Identifiers

PMID35646902
PMCPMC9136019
OpenAlexW4280574394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.