Evidence map›Paper›PMID 35646891›Full record

ArticleFrontiers in cell and developmental biology2022

Signaling Proteins Recruited to the Sperm Binding Site: Role of β-Catenin and Rho A.

Huizhen Wang, William H Kinsey

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Juno and CD9 protein network organization in oolemma of mouse oocyte.Frontiers in cell and developmental biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Huizhen WangDepartment of Anatomy & Cell Biology, University of Kansas School of Medicine, Kansa City, KS, United States.
William H KinseyDepartment of Anatomy & Cell Biology, University of Kansas School of Medicine, Kansa City, KS, United States.
University of Kansas · US

Funding

PYK2 function during fertilizationR01HD062860 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KINSEY, WILLIAM H. · 2010 to 2020
$2.9M
CONFOCAL LIVE CELL IMAG: REPRODUCTIVE SCI: MATERNAL FETUS INTERFACE, HEART DVMTS10RR019279 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI KINSEY, WILLIAM H. · 2004 to 2004
$270k
NCRR NIH HHS S10 RR019279NICHD NIH HHS R01 HD062860
6 · The paper itself

Abstract

Sperm interaction with the oocyte plasma membrane triggers a localized response in the mouse oocyte that leads to remodeling of oocyte surface as well as the underlying cortical actin layer. The recent demonstration that PTK2B is recruited and activated at the sperm binding site raised the possibility that multiple signaling events may be activated during this stage of fertilization. The present study demonstrated that β-catenin and Rho A were recruited to the cortex underlying bound/fused sperm. To determine whether sperm-oocyte contact was sufficient to initiate β-catenin recruitment,

Indexed as

actincortexfertilizationoocyteRho Aβ-catenin

Identifiers

PMID35646891
PMCPMC9136404
OpenAlexW4280557434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.