ArticleFrontiers in bioengineering and biotechnology2022
Implementation of Perforated Concentric Ring Walls Considerably Improves Gas-Liquid Mass Transfer of Shaken Bioreactors.
Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Computational Fluid Dynamic Analysis of Fluid Motion and Volumetric Gas-Liquid Mass Transfer in Agitated Platelet Concentrate Storage.Biotechnology journal · 2026Article
- Effect of High-Speed Shaking on Oxygen Transfer in Shake Flasks.Biotechnology journal · 2025Article
- Diffusion-driven fed-batch fermentation in perforated ring flasks.Biotechnology letters · 2024Article
- Gas supply apparatus using rotational motion of shaking incubator for flask culture of aerobic microorganisms.Engineering in life sciences · 2024Article
- Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation.Bioengineering (Basel, Switzerland) · 2024Review
- A forced aeration system for microbial culture of multiple shaken vessels suppresses volatilization.Archives of microbiology · 2024Article
- Validation of computational fluid dynamics of shake flask experiments at moderate viscosity by liquid distributions and volumetric power inputs.Scientific reports · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
Since their first use in the 1930s, shake flasks have been a widely used bioreactor type for screening and process development due to a number of advantages. However, the limited gas-liquid mass transfer capacities-resulting from practical operation limits regarding shaking frequency and filling volumes-are a major drawback. The common way to increase the gas-liquid mass transfer in shake flasks with the implementation of baffles is generally not recommended as it comes along with several severe disadvantages. Thus, a new design principle for shaken bioreactors that aims for improving the gas-liquid mass transfer without losing the positive characteristics of unbaffled shake flasks is introduced. The flasks consist of cylindrical glass vessels with implemented perforated concentric ring walls. The ring walls improve the gas-liquid mass transfer
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Registered trials
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